Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Right Heart Failure"”.
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Assessing Risk For Right Heart Failure After Left Ventricular Assist Device Implantation
… negatively impacted by the diagnosis of Advanced Heart Failure. Financial burden, repeated hospitalizations, and declining quality of life account for poor outcomes. Implantation of a left ventricular assist device (LVAD) has offered the promise of improved financial, clinical, and functional …
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Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
Right ventricular function (RV) is one of the most important predictors of prognosis in many cardiovascular disease states. Despite the significance of RV function to survival, there are no therapies that directly nor selectively improve RV function. As well, the basis for RV failure is poorly …
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Pulmonary hypertension in adolescents with sickle cell disease
… causing less blood to reach the lungs. The right side of the heart has to pump harder to compensate for this, which can ultimately lead to right heart failure. With vaso-occlusion being the major complication in sickle cell disease and affecting many tissues and organs like the lungs, …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… cardiovascular disorder, which leads to right heart failure and death, if left untreated. Heterozygous germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… cardiovascular disorder, which leads to right heart failure and death, if left untreated. Heterozygous germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 …
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Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
… by elevated pulmonary vascular resistance, right ventricular hypertrophy, right heart failure and ultimately death. This disease has no current cure and available therapies alleviate vasoconstriction but do not address the disorder associated vascular remodelling. Amplified activity of …
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Der Einfluss der hämodynamischen Druckbelastung des rechten Ventrikels auf die Expression pro- und anti-inflammatorischer Zytokine bei Neugeborenen : eine tierexperimentelle Untersuchung
The function of the right ventricle is an important parameter to evaluate the prognosis of neonates suffering from complex congenital heart defects, pulmonary stenosis or pulmonary hypertension. In these patients the right ventricle is often exposed to a major chronic pressure overload. Even though …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… arterial pressure eventually leading to right heart failure. Loss of function mutations in the bone morphogenetic protein (BMP) pathway are known to be causative for PAH. Mutations in the type II receptor BMPR-II are the main cause of familial PAH and are also found in sporadic idiopathic …
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Leveraging Right and Left Ventricular Coupling for Optimization of Mechanical Circulatory Support
… mechanical support risks decompensation if the heart and lung cannot tolerate these changes. One particularly concerning consequence of altered coupling is that upwards of 40% of patients with left-sided mechanical support face ensuing right heart failure, which requires urgent action and often …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… increase in pulmonary arterial pressure and right ventricular afterload ultimately causes death by right heart failure. Current available treatments show little impact on patient mortality and there is thus an urgent need to better understand the causes of PAH pathology to derive new …