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Showing 1 to 20 of 21 for “"Rift Valley fever virus"”.
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Host response to Rift Valley fever virus infection
Rift Valley fever virus (RVFV) has the ability to cause severe disease (in the form of encephalitis or hemorrhagic fever) in humans and animals. RVFV is endemic to parts of Africa and the Arabian Peninsula, but there is significant concern regarding its potential introduction into non-endemic …
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The development of novel diagnostic countermeasures for Rift Valley fever virus
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that is a significant threat to livestock and humans. It is listed as #3 for most dangerous animal threats and is in the top 10 pathogens needing urgent research in preventative and control measures. Although RVFV has never been reported in the …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
Rift Valley fever virus (RVFV) is a phlebovirus of the virus family, Bunyaviridae. Since the early 1900s, RVFV has continually caused economically devastating outbreaks in livestock and severe disease in humans. In pregnant ewes, RVFV infection can cause abortions in up to 100% of animals and high …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
Rift Valley fever Phlebovirus (RVFV) ist ein Mitglied der Familie Bunyaviridae. Es wird durch Stechmücken übertragen und ist in der Lage zahlreiche Wirtspezies zu infizieren. Beim Menschen kann die Infektion zu Hepatitis, hämorrhagischem Fieber und Enzephalitis mit tödlichem Ausgang führen. Bei …
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Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana
Rift Valley fever (RVF) is a haemorrhagic fever agent caused by an infection with an enveloped negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
Rift Valley fever virus (RVFV) is a negative-sense RNA virus that is classified as an overlap select agent by the USDA and the HHS. It was first discovered in the Rift Valley of Kenya in the early 1930s. RVFV is an arbovirus that is transmitted by mosquitoes and infects ruminants and humans. RVFV …
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Reverse genetics system and fucntion of NSM protein of Rift Valley fever virus (family Bunyaviridae, genus phlebovirus)
Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease that is endemic in sub-Saharan African countries and results in large epidemics among humans and livestock. Furthermore, it has potential as a …
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The Impact of the Non-Structural Small Segment Gene on Host Immune Responses Against Rift Valley Fever Virus
Rift Valley fever virus (RVFV) is responsible for large periodic outbreaks of enzootic hepatitis of ruminants. Inevitably, due to the close proximity and relationship between, the mosquito vector species, livestock, and humans, infection spreads to humans causing a range of mild to severe clinical …
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Comparison of the two lumpy skin disease virus vaccines, Neethling and Herbivac, and construction of a recombinant Herbivac-Rift Valley fever virus vaccine
… compare and characterise two lumpy skin disease virus (LSDV) vaccines namely the vaccine based on attenuated Neethling LSDV (nLSDV) and Herbivac®LS (Herbivac). The second aim is to construct a recombinant LSDV expressing Rift Valley fever virus (RVFV) genes. An LSDV vaccine is critical for …
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Rôle des moustiques Culicidae, de leurs communautés microbiennes et des réservoirs vertébrés, dans la transmission des arbovirus à Madagascar
… was available about the local dynamics of the virus transmission and identity of the vector species and vertebrates réservoirs involved. Madagascar island was chosen for its high endemic biodiversity, contrasting climatic conditions and drastic changes in habitats due to an increase anthropic …
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes significant morbidity and mortality in both humans and animals. In humans, the disease manifests itself as febrile illness, hemorrhagic fever, encephalitis, or retinitis. In animals, RVFV causes high rates of abortions and fetal …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
Several arthropod-borne bunyaviruses cause encephalitic disease in humans, primarily infecting neurons in the brain. Two of the most prominent examples are Rift valley fever virus (RVFV), and La Crosse virus (LACV). These viruses may preferentially infect neurons due to dampened neuronal innate …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen, which affects both humans and livestock. RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and …
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A GIS Analysis of the Environmental Variables Related to Rift Valley Fever Outbreaks
<p>Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
Oropouche virus (OROV) is an arthropod-borne virus that infects several species of animals and humans, primarily in Central and South America. Despite being described as a human pathogen more than 60 years ago and of its public health significance, little progress has been made towards describing …
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Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.
Hemorrhagic fever viruses (HFVs) pose significant global health and economic burdens, yet limited FDA-approved therapeutics exist to combat their spread. Determining alterations in host processes during infection can enhance our understanding of viral replication and lead to potential host-based …
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Epidemological investigations of rift valley fever in livestock in three ecological zones of Malawi.
Due to uncertainty on the status of Rift Valley fever (RVF) in Malawi, limited knowledge about its epidemiology, and debates on whether it is a real or perceived threat for the livestock and human population in the country, a study was formulated to investigate the epidemiology of RVF. The study …
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Epidemiological investigations of rift valley fever in livestock in three ecological zones of Malawi.
Due to uncertainty on the status of Rift Valley fever (RVF) in Malawi, limited knowledge about its epidemiology, and debates on whether it is a real or perceived threat for the livestock and human population in the country, a study was formulated to investigate the epidemiology of RVF. The study …
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