Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Rifampicin resistance"”.
-
Investigating the Double-Edged Sword of Rifampicin Resistance in Mycobacterium Tuberculosis
… that is resistant to the first line antibiotic rifampicin (Rif). Rif resistant (RifR) Mtb caused up to 450,000 cases of TB and 264,000 deaths worldwide in 2021. Treatment for drug resistant TB is even more arduous, consisting of expensive second- and third-line antituberculars with side effects …
-
Substandard antimicrobial drugs: detection methods and their contributions to antibiotic resistance
… substandard medicines and the evolution of rifampicin resistance. This dissertation advanced two technologies that may aid in the detection of substandard medicines: aptamers and biosensors. Oligonucleotide aptamers may be adapted for drug detection by coupling binding events to changes in …
-
Novel Diagnostic approach for tuberculosis diagnosis
… load in the sample and simultaneously detects rifampicin resistance. This study was part of a cross-sectional, multi-centre clinical trial. The Cape Town component of this study was conducted at three sites, one hospital based and other two community clinics, all with high TB/HIV coinfection …
-
Assessment of Two Techniques for Diagnosis Pulmonary Tuberculosis in HIV Patient at Mnazi Mmoja Hospital Zanzibar.
… of Mycobacterium tuberculosis as well as rifampicin resistance for HIV patients. The specimens were processed in Gene Xpert MTB/RIF and smear auramine LED FM. The sum of 246 patients sputum specimens were analyzed for the existence of Mycobacterium tuberculosis by means of Gene Xpert …
-
Evaluation of diagnostic advances in musculoskeletal tuberculosis; the automated xpert MTB/RIF assay
… accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as secondary objectives. The overarching hypothesis was that …
-
Rifampicin-resistant Mycobacterium tuberculosis: an emerging threat to human health in Botswana
Rifampicin-resistant tuberculosis (RR-TB) continues to threaten global TB control. The World Health Organisation (WHO) estimated that 400,000 people developed RR-TB in 2023, with Africa being among the regions with the highest burden. Botswana, a high TB/HIV burden country, has reported an increase …
-
Diagnosis, treatment and determinants of mortality in patients hospitalized with HIV-associated tuberculosis
… mortality included tuberculosis dissemination, rifampicin resistance and having features of sepsis syndrome. Using principal components analysis, we characterised an innate immune profile which was associated with mortality and with biomarkers of disseminated tuberculosis. A large proportion of …
-
The Epidemiology and Evolution of Rifampicin Mono Resistant Tuberculosis in Khayelitsha, Cape Town, South Africa
… World Health Organization Global TB report 2018, rifampicin monoresistant tuberculosis (RMR-TB) comprises 22% and 38% of all rifampicin-resistant TB (RR-TB) globally, and within South Africa, respectively. National surveys from South Africa show an increasing proportion of RMR-TB among TB cases …
-
Xpert MTB/RIF Ultra and mycobacterial culture in routine clinical practice at a Tertiary Paediatric Hospital
… over smear microscopy, and ability to detect rifampicin resistance despite culture being the “gold standard”. This study reviewed published literature on current childhood tuberculosis diagnostic modalities. It also retrospectively compared demographic, clinical, and radiological features of …
-
Evaluation of diagnostic advances in Musculoskeletal Tuberculosis; the automated xpert MTB/RIF assay
… accuracy of Xpert for musculoskeletal TB and for rifampicin resistance against a gold standard of culture or histology. Site of disease, HIV status, and age of patients, and accuracy in spinal compared to extraspinal TB were investigated as secondary objectives. The overarching hypothesis was that …
-
Factors associated with mortality among Tuberculosis patients on treatment in Limpopo Province, South Africa, from 2013 to 2018
… defaulted were 5.7%, the MDR cases were 0.2, the Rifampicin resistance were 0.3% and 0.6% for treatment failure. There is a gradual decrease in the death rate, from 2013 at 14.7 % to 7.4% in 2018. There was a statistically significant association between death and gender. The mortality rate among …
-
Developmental genetic studies on Thiobacillus ferrooxidans
… coli auxotrophic mutants. Clones that conferred resistance to methyl methane sulfonate (MMS), a DNA-damaging agent, were isolated in an E. coli recA⁻ mutant. In an attempt to clone a homologous marker, T. ferrooxidans ATCC 33020 was mutated to rifampicin resistance (Rifʳ) and DNA from the mutant …
-
Prevalence of drug-resistant tuberculosis and associated risk factors among patients in the Northern Region of South Africa
… are challenged by the emergence of drug resistance to more anti-TB drugs resulting in multi-drug resistant TB (MDR-TB), pre-extensively drug-resistant TB (pre-XDR-TB) and XDR-TB. Globally, about 465,000 people have rifampicin-resistant TB (RR/TB; 78% MDR-TB), where new cases contribute …
-
Characterization of Mycobacterium tuberculosis isolates with discordant rifampicin susceptibility test results
… National TB Control programme in December 2010. Rifampicin (RIF) resistance detected by the Xpert MTB/RIF (Xpert) is confirmed by a line probe assay (LPA) (GenoType MTBDRplus) and/or phenotypic (culture-based) drug susceptibility testing (DST) by MGIT (Mycobacterial Growth Indicator Tube) on the …
-
Studies into Transcriptional Pausing Regulators and Drug Resistance in Mycobacterium Tuberculosis
… TB therapy, which further exacerbates antibiotic resistance. Approximately 400,000 people develop drug-resistant TB each year. Therefore, new drug targets are desperately needed. Considering this, we are studying the transcription cycle of Mtb, which is regulated differently than the well-studied …
-
Genetic and pharmacokinetics factors associated with susceptibility to kanamycin induced cochleotoxicity in a cohort of patients undergoing MDR/RR-TB treatment
… of multidrug-resistant tuberculosis (MDR-TB) and rifampicin resistance tuberculosis (RR-TB). The standard MDR/RR-TB regimen prescribed in South Africa, at the time of the present study included Kanamycin, an aminoglycoside with a known cochleotoxic effect. Although kanamycin has recently been …
-
Genome - Wide Regulatory Principles of Essential Transcription Factors from Mycobacterium Tuberculosis
… therapeutic target. Most notably, the antibiotic rifampicin targets RNAP in the bacterial pathogen <em>Mycobacterium tuberculosis</em> (<em>Mtb</em>) and has therefore been a cornerstone of the frontline therapeutic regimen to treat tuberculosis (TB) since the 1960s. However, the rise of …
-
Impatto di rifaximina sul microbiota intestinale: selezione di bifidobatteri antibiotico resistenti
… the enteric area minimizes both antimicrobial resistance and systemic adverse events. Fermented dairy products enriched with probiotic bacteria have developed into one of the most successful categories of functional foods. Probiotics are defined as “live microorganisms which, when administered …