Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rif1"”.
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Identification and Characterization of the DNA Damage Response Function of Human Rif1 and a Search For Human Rap1 Interacting Factors
<p>Rifl, the ortholog of the yeast Rapl interacting factor 1, a telomere length regulator was identified. Immunofluorescence did not reveal an association of human Rifl with telomeres. Preliminary co-immunoprecipitation with known telomeric proteins and chromatin immunoprecipitation failed to show …
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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… components of CSR are 53BP1 and its effector RIF1 because they inhibit end resection to promote NHEJ and oppose competing pathways in DDR. However, the mechanism by which RIF1 effects end-protection in CSR and binds to 53BP1 is still unknown In these studies, I identified a novel component of …
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53BP1 and double-strand break repair pathway choice in cancer
… The mechanism by which 53BP1 (together with RIF1 and MAD2L2) promote NHEJ remains elusive. Genome instability in HR-defective cancers, principally those harbouring a mutation in BRCA1, can be rescued by the concomitant loss of either 53BP1, RIF1 or MAD2L2. This phenomenon has relevance for …
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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… that 53BP1 and its downstream effectors RIF1 and the shieldin complex limit the generation of long 3' overhangs at DSBs by recruiting CST/Polα to counteract resection, challenging the long-standing model of a block to resection by this pathway. Like loss of 53BP1/RIF1/shieldin, disruption …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… PDX model (PATC55). I found a truncating <em>RIF1</em> DNA mutation at the BRCA interacting site. Additional shRNA targeted knockdown of <em>RIF1</em> did not induce resistance, however single cell RNA sequencing of Talazoparib-treated cells did demonstrate high expression levels of SHFM1, …
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Mechanisms of genomic stability maintenance in fission yeast
… to centromeres were measured for wild type and Rif1Δ cells. We noticed that, Rif1 selectively affects the positioning of Rif1-regulated ORIs, pointing to a differential role for the protein in chromatin organization. The temporal separation between licensing and initiation ensures the once and …
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Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases
… interaction between 53BP1 and RIF1 independently of the Shieldin and CST complexes, which we propose serves to physically hold DSB ends together in a redundant manner with the core NHEJ-mediated end synapsis machinery. Second, we propose that ATM promotes EF-NHEJ via promoting …