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Showing 1 to 20 of 24 for “"Ribosome assembly"”.
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Ribosome Assembly in Heat-Injured Staphylococcus Aureus Mf-31
Made available in DSpace on 2014-12-13T19:47:43Z (GMT). No. of bitstreams: 1 7913456.pdf: 5521728 bytes, checksum: f96c84052934c738ea1efe72273c026d (MD5) Previous issue date: 1978
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The Evolution of Ribosome Assembly: Making Ribosomes in the Mitochondria
<p>Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the mitochondrial genome that are assembled into oxidative phosphorylation complexes. As such, the biogenesis of mitoribosomes is essential for ATP production and cellular metabolism. Despite significant progress in …
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eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae
Ribosomes are ribonucleoprotein complexes in charge of protein translation. Translation is an essential process in all organisms that involves decoding the information contained in mRNAs (messenger RNAs) to generate proteins. Similarly, the process of ribosome biogenesis represents a critical …
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An Investigation into the Effects of Alterations in Ribosomal Proteins S4 and S5 on Translational Accuracy, Ribosomal RNA Processing, and Ribosome Assembly
… in gene expression and is carried out by the ribosome. Ribosomal proteins S4 and S5 are critical for the decoding and the assembly processes on the ribosome. The interaction between residues in the S4-S5 interface region is crucial for the large scale conformational changes occurring on the …
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Making Ribosomes: Biochemical and Structural Studies of Early Ribosome Biogenesis in Yeast
<p>The ribosome is a complex macromolecule responsible for the synthesis of all proteins in the cell. In yeast, it is made of four ribosomal RNAs and 79 proteins, asymmetrically divided in a small and large subunit. In a growing yeast cell, more than 2000 ribosomes are assembled every minute. The …
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Dissecting SBDS function in Arabidopsis thaliana
Ribosome biogenesis has been extensively studied across various organisms, yet its complex mechanisms in plants remain underexplored. The SBDS protein, a highly conserved factor across eukaryotes, is essential for ribosome maturation and function. Interestingly, the Arabidopsis thaliana SBDS …
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Genetic and cytological investigation of Nucleostemin-1 in Drosophila melanogaster
… cycle progression, stem cell proliferation, and ribosome assembly. Drosophila melanogaster contains a four-member nucleostemin family (NS1-4). Nucleostemin 1 (NS1) is the closest orthologue to human NS; it shares 33% identity and 67% similarity with human NS. We show that NS1 has intrinsic GTPase …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… KSHV pathogenesis. Nucleolin (NCL), involved in ribosome assembly, pre-mRNA metabolism, cytoplasmic RNA stability, and nucleo-cytoplasmic transport as well as ORF57, an mRNA transcript accumulation (MTA) viral early protein involved in posttranscriptional regulation, splicing of viral RNA …
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Elucidation of the Functional Architecture of the Early Pre-Ribosomal Processing Machinery in Yeast
<p>Ribosomes carry out one of the most fundamental functions of life - the translation of genetic information into functional proteins. The pivotal role of the ribosome in the cell is reflected in its immensely complicated and energy-consuming assembly pathway. The maturation of a eukaryotic …
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
<p>The ribosome is the RNA-protein machine responsible for the essential task of translating mRNA into proteins. Ribosomes are heterodimers made up of a small subunit (SSU, 40S) and a large subunit (LSU, 60S). At the interface of these subunits, the mRNA is decoded by the small subunit and peptide …
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Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis
<p>Cellular proteins are synthesized by ribosomes, which are ~3 MDa macromolecular complexes comprised of four ribosomal RNAs and ~80 ribosomal proteins in yeast. The biogenesis of such complicated ribonucleoprotein complexes is a highly regulated, multistep process requiring a plethora of more …
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Synthesis, Screening and Cocrystallization of Adenosine Based Inhibitors with Methyltransferases, ErmC' and KsgA
… lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (SAM) as their methyl source, which binds adjacent to their specific adenosine …
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Nucleolar Stress Due to Depletion of Nopp140 in Drosophila melanogaster
Nucleolar stress results when ribosome biogenesis is disrupted. An excellent example is the human Treacher Collins syndrome in which the loss of the nucleolar chaperone, Treacle, leads to p53-dependent apoptosis in embryonic neural crest cells, and ultimately to craniofacial birth defects. We show …
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Mass Spectrometry-Based Characterization Of Chloroplast Protein Complexes And Clp Protease Function
… the essential contribution of ClpP3 in Clp core assembly and function, as well as the crucial role of the Clp core complex in chloroplast viability. Large-scale, label-free quantification was used to characterize large (>800 kDa) soluble, chloroplast-localized protein and nucleoprotein assemblies …
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The role of RNA modifications in mitochondrial translation
… is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. However, little is known about their role in terms of mitochondrial translation and/or ribosome assembly. The mitochondrial …
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Studying the Interaction of RACK-1 and GLD-1 in the Germline of Caenorhabditis elegans
… decision of GSCs. RACK-1 is involved in ribosome assembly and the miRISC pathway. Meanwhile, GLD-1 functions in germline stem cell entry and progression through meiosis as well as oogenesis and sex determination. Previous work had shown that an absence of rack-1 results in lower GLD-1 …
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INTEGRATED TRANSCRIPTOMIC AND TRANSLATIONAL PROFILING OF EIF6-SBDS IN SHWACHMAN-DIAMOND SYNDROM REVEALS DIFFERENT CELLULAR STATES SHAPED BY RIBOSOME COMPOSITION AND FIDELITY
Ribosome biogenesis is an essential and tightly regulated process that underpins cellular growth, proteostasis, and metabolic homeostasis. Disruptions in its final cytoplasmic maturation steps can profoundly alter translational output and lead to human disease. Shwachman–Diamond syndrome (SDS) …
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Mechanisms and Evolution of Mitoribosomal Small Subunit Biogenesis
<p>The ribosome is the macromolecular machine responsible for all protein synthesis in the cell and is one of the ancient molecular machines involved in the transfer of genetic information to functional molecules. The ribosome is made up of two conserved ribonucleoprotein complexes: the large …
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