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Showing 1 to 20 of 424 for “"Ribosome"”.
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Ribosome-catalyzed ester formation.
Massachusetts Institute of Technology. Dept. of Biology. Thesis. 1970. Ph.D.
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Investigation of Ribosome Structure and Ribosome-Transfer Rna Interaction Using T4 Rna Ligase
… of E. coli ribosomal RNAs in the intact polyribosome, ribosome and subunits. This enzyme will catalyze the addition of a 3',5'-bisphosphate onto the 3' terminus of rRNAs resulting the rRNA molecules one nucleotide longer with a 3' phosphate. The RNA ligase catalyzed addition of radioactively …
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Studies on Ribosome-Membrane Interaction
… the relationship between free and membrane-bound ribosomes and of the ribosome-membrane interaction were investigated in a rat liver cell-free system. a) When nascent polypeptide chains were terminated by incubating rough microsomes in a medium optimal for amino acid incorporation, a subsequent …
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A General Platform for Ribosome Engineering
… approach. However, the properties of the natural ribosome limit existing work to close analogues of the canonical amino acids. This thesis develops a directed evolution technology to engineer ribosomes in vitro. The focus of this work is to create a general platform capable of identifying ribosome …
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Evolution and assembly of the ribosome
The ribosome is a large macromolecular assembly responsible for protein synthesis in all living cells. A typical bacterial ribosome consists of three ribosomal RNA (rRNA) molecules and approximately fifty ribosomal proteins (r-proteins), which are arranged into two subunits of unequal size and …
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Investigating the Molecular Mechanism of Ribosome Recycling
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds of translation, has been largely overlooked. …
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The origin and evolution of the ribosome
THE ORIGIN AND EVOLUTION OF THE RIBOSOME Ajith Harish, Ph.D. Program in Physiological and Molecular Plant Biology University of Illinois at Urbana-Champaign, 2010 Prof. Gustavo Caetano-Anollés, Advisor The ribosome coordinates one of the most fundamental biological processes, protein biosynthesis. …
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Biogenesis and Function of the Mitochondrial Ribosome
… and function of the human mitochondrial ribosome. The mammalian mitochondrial ribosome (mitoribosome) is one of the largest ribonucleoprotein complexes in the cell, with the overall molecular mass of the fully assembled 55S monosome being ~2.7 MDa. It is indispensable for cell survival, …
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The Ribosome and Its Role in Early Development.
The cells of any given multicellular organism arise from a single fertilized egg by mitotic divisions. This implies that every cell has the same chromosomal content and thus the same genetic information. Such an assumption was verified by Gurdon (1962) who transplanted nuclei from single somatic …
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INVESTIGATING THE ROLE OF SPECIALIZED RIBOSOME DURING ERYTHROPOIESIS
Eukaryotic ribosomes are made up of ~80 ribosomal proteins (RPs) and 4 ribosomal RNAs (rRNAs), and are traditionally thought to be invariant in all cells. Recent studies have found that ribosomes can be heterogeneous in different cell types, and can regulate translation of specific subsets of …
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A Pseudoknot Improves Selection Efficiency in Ribosome Display
The size and diversity of ribosome display libraries depends upon stability of the complex formed between the ribosome, mRNA and translated protein. To investigate if mRNA secondary structure improves stability of the complex, I tested a pseudoknot, originating from the genomic RNA of infectious …
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Structural analyses of the ribosome by hybrid approach
The ribosome is the molecular machine which reads and translates genetic information into proteins in all living cells. Lack of an atomic-resolution structure of the ribosome in its actual functional states prevents our understanding of the ribosome. A hybrid approach overcomes the challenge by …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
… RNA regulation. Here we characterize two ribosome-associated proteins that are important for miRNA biogenesis. In one study, we identified nucleolin as a positive regulator of pri-miR-15a/miR-16-1 biogenesis. Nucleolin expression is inversely proportional to mature miR-15a/miR-16-1 …
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Ribosome Assembly in Heat-Injured Staphylococcus Aureus Mf-31
Made available in DSpace on 2014-12-13T19:47:43Z (GMT). No. of bitstreams: 1 7913456.pdf: 5521728 bytes, checksum: f96c84052934c738ea1efe72273c026d (MD5) Previous issue date: 1978
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Translation-Mediated Stress Responses: Mining of Ribosome Profiling Data
… cellular mRNA fragments protected by translating ribosomes, dubbed ribosome profiling. This approach allows detection of differential translation activity, annotation of novel protein coding sequences and variants, identification of ribosome pause sites and estimates of de novo protein synthesis. …
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Cell Targeted Ribosome Inactivating Proteins Derived from Protein Combinatorial Libraries
… within the catalytic A subunit of the bacterial ribosome-inactivating protein (RIP) known as Shiga-like toxin 1 (SLT-1). More precisely, a seven amino acid peptide epitope (PDTRPAP) was inserted between residues 245-246 of its A subunit (SLT-1APDTRPAP) and shown to preserve catalytic function …
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