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Showing 1 to 4 of 4 for “"Ribosomally synthesized and posttranslationally modified peptides (RiPPs)"”.
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… route to peptide natural products involves ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the largest classes of RiPPs is the lanthionine-containing peptides (lanthipeptides), which are characterized by intramolecular thioether crosslinks dubbed lanthionine …
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Mechanistic Insights into MftR-Dependent Regulation of the Redox Cofactor Mycofactocin
… are essential for life. While classic flavins and nicotinamides are widely distributed across all domains of life, nature has also evolved niche cofactors in subsets of life domains. For example, in <em>Actinobacteria</em>, coenzyme F420 is commonly used in place of flavin mononucleotide in …
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Elucidation and control of substrate recognition during RiPP biosynthesis
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products. RiPP precursor peptides can undergo extensive enzymatic tailoring to yield structurally and functionally diverse products. Cyclodehydratases are a type of RiPP modifying enzyme …
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Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides
Lanthipeptides are natural products that belong to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs). They contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) structures that contribute to their diverse biological activities. ProcM is a …