Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Ribosomally synthesized and post-translationally modified peptide (RiPP)"”.
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Development Towards an Ethylene Sensing Artificial Metalloenzyme
… ripening hormone for climacteric plants, and consequently its detection and quantification is of considerable interest to the horticulture industry. Its detection however is a non-trivial pursuit, traditionally requiring expensive and inaccessible instrumentation that fail to provide in …
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Biosynthetic engineering of plantazolicin natural products
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, Bacillus anthracis. During PZN biosynthesis, a cyclodehydratase catalyzes …
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New Insights into Mycofactocin Biosynthesis, Structure and Function
<p>Mycofactocin is a putative ribosomally synthesized and post-translationally modified peptide (RiPP)-derived redox cofactor. Its biosynthesis is accomplished through the dedicated actions of the products of six conserved genes, <em>mftABCDEF</em>. The mycofactocin pathway is one of the most …
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Studies on the mechanism of action of the antimicrobial S-linked glycopeptide sublancin
… making it difficult to develop drugs with new and unique modes of action by generating analogs. Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are a rapidly expanding class of compounds with antimicrobial activity. Sublancin is one of five members of …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… rise in antibiotic- resistant pathogens. Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are genetically encoded peptide-derived secondary metabolites whose structures can be predicted based on gene sequence and identity of tailoring enzymes within …
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Revealing the molecular details of azoline formation in ribosomal natural product biosynthesis
The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large chemical and functional space and are linked by the presence of the …