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Showing 1 to 7 of 7 for “"Ribosomal Subunit Assembly"”.
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Characterization of 50S Ribosomal Subunit Assembly Inhibition in Erythromycin Treated <em>Escherichia coli</em> Cells.
… shown that erythromycin also inhibits the assembly of the 50S ribosomal subunit in growing bacterial cells. The nature of this assembly inhibition has been investigated using <sup>3</sup>H-uridine pulse-chase labeling of control and erythromycin treated <em>E. coli</em> cells.</p> …
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30S Ribosomal Subunit Assembly is a Target for Inhibition by Aminoglycoside Antibiotics in <em>Escherichia coli</em>.
<p>Antibacterial agents specific for the 50S ribosomal subunit not only inhibit translation but also prevent assembly of that subunit. I examined the 30S ribosomal subunit in growing <em>Escherichia coli</em> cells to see if antibiotics specific for that subunit also had a second inhibitory effect. …
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Antibiotics that Inhibit 30S or 50S Ribosomal Subunit Formation: Hygromycin B, Quinupristin-Dalfopristin and XRP 2868.
… that prevent translation by binding to ribosomal subunits have been shown to also inhibit ribosomal subunit assembly (Champney and Tober 2003). The aminoglycoside hygromycin B was examined in <em>Escherichia coli</em> cells for inhibitory effects on translation and ribosomal subunit …
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Degradation of 23S rRNA in Azithromycin-Treated Ribonuclease Mutants of <em>Escherichia coli</em>.
… antibiotic, specifically binds to the 50S ribosomal subunit of bacterial ribosomes and inhibits translation. Azithromycin also prevents 50S ribosomal subunit assembly by binding to a 50S ribosomal subunit precursor particle. When exposed to azithromycin, several ribonucleases in wild-type …
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Assembly of the 30S ribosomal subunit: positioning of ribosomal protein S13 in the S7 assembly branch
<p>Studies of Escherichia coli 30S ribosomal subunit assembly have revealed a hierarchical and cooperative association of ribosomal proteins with 16S ribosomal RNA; these results have been used to compile an in vitro 30S subunit assembly map. In single protein addition and omission studies, …
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
… macrolides specifically target the 30S or 50S subunits to inhibit bacterial growth. During the assembly of the bacterial ribosome, ribosomal RNA of the 30S and 50S ribosomal subunits is processed by bacterial ribonucleases (RNases). RNases are also involved in the degradation and turnover of …
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Studies on a 50S Ribosomal Precursor Particle as a Substrate for <em>erm </em>E Methyltransferase Enzyme in <em>Staphylococcus aureus </em>.
… inhibits not only mRNA translation but also 50S ribosomal subunit assembly in bacterial cells. An important mechanism of erythromycin resistance is the methylation of 23S rRNA by <em>erm</em> methyl transferase enzymes. We are interested in investigating the true substrate for methylation because …