Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Ribonucleoprotein particles"”.
-
Molecular analysis of wheat snRNAs
… together. This process is mediated by small ribonucleoprotein particles (snRNPs), formed from small nuclear RNAs (snRNAs) and their associated nuclear proteins.
-
Untersuchungen zur Biogenese spleißosomaler UsnRNPs und ihrer Bedeutung für die Pathogenese der SMA
… spleißosomaler UsnRNPs (U-rich small nuclear ribonucleoprotein particles). Diese Arbeit zeigt in einem SMA-Modell in Hela-Zellkultur, dass der SMN-Mangel zu einer reduzierten de novo-Produktion der spleißosomalen UsnRNPs führt. In einem Zebrafisch-Modell für SMA wurde nachgewiesen, dass die …
-
STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… that SYK can associate with stress granules, ribonucleoprotein particles that form in stressed cells and contain inactive translation initiation complexes. I found that microglial cell lines and primary mouse brain microglia, when stressed by exposure to sodium arsenite or Aβ(1-42) peptides or …
-
Structural characterization of a protein/RNA complex : human TAP/NXF1 protein/retroviral CTE RNA
… proteins that bind the mRNA, packing it into ribonucleoprotein particles (mRNPs). In humans, the protein TAP/NXF1 interacts with mRNA export cargoes and mediates their nuclear export by shuttling through nuclear pore complexes (NPCs). TAP is a multidomain modular protein composed of an …
-
Genome Organization And Expression Of Selected Potexviruses
… ability of partially encapsidated PMV and CYMV ribonucleoprotein particles to direct protein synthesis has also been assessed. As the extent of encapsidation increased, the relative synthesis of the high molecular weight products decreased markedly. In contrast, the synthesis of the in vitro …
-
Essential Protein Factors in pre-mRNA splicing : A Structural Study by Nuclear Magnetic Resonance Spectroscopy
… proteins are common components of small nuclear ribonucleoprotein particles (snRNPs), which are assembled by a protein complex that contains SMN. The structure of the SMN Tudor domain exhibits a five stranded ?-barrel, which resembles the fold of Sm proteins. The Tudor domain of SMN binds to …
-
On co-transcriptional splicing and U6 snRNA biogenesis
… interact with the pre-mRNA are the small nuclear ribonucleoprotein particles (snRNPs). They consist of one of the U-rich snRNAs U1, U2, U4, U5 or U6 together with several particle-specific proteins and core proteins. All mRNA processing events can occur co-transcriptionally, i.e. while the RNA is …
-
Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… reading frame proteins and formation of LINE-1 ribonucleoprotein particles. By controlling dysregulated LINE-1 retrotransposition, RNase L could contribute to the maintenance of genomic stability and fulfill its tumor suppressor function. The interaction between RNase L and APOBEC3G during HIV-1 …
-
Mechanisms of dynein-based mRNA transport processes in human cells
… and that they link dynein-BICD2 to components of ribonucleoprotein particles (RNPs), including ribosomal proteins. Ribosomal proteins were shown to interact with dynein and BICD2 in a nascent chain-dependent manner, supporting the existence of a co-translational mRNA transport mechanism. …
-
Mining common genetic Variants impacting on Allele-Specific Translation and cancer risk
… revealed that both alleles localize similarly to ribonucleoprotein particles (RNPs) and 40S ribosomal subunits, suggesting functional similarity. Notably, the alternative allele produced higher levels of functional eIF4H protein, suggesting the rs1554710467 as a potential gain-of-function variant. …
-
Mass Spectrometric Analyses of Post-Translationally Modified Proteins
… Proteinen des U1 snRNPs (small nuclear ribonucleoprotein particles) identifiziert. Von diesen waren 59 Phosphorylierungsstellen bisher unbekannt. Kapitel 4 (Pseudo-Neutral-Loss Scan for Selective Detection of Phosphopeptides and N-Glycopeptides using Liquid Chromatography Coupled with a …
-
Genetic, Biochemical, and Electron Microscopic Analysis of Components Involved in Transcription Coupled mRNA Export
… after extensive processing and assembly into ribonucleoprotein particles (RNPs). Studies in yeast have identified many components involved in mRNA export. These include nuclear pore proteins, export receptors and components in the nucleus that couple formation of mRNPs with translocation …
-
Structural and functional characterization of proteins involved in the biogenesis of spliceosomal U snRNPs
… (engl.: uridyl-rich small nuclear ribonucleoprotein particles, UsnRNPs). Die Biogenese der UsnRNPs schließt in höheren Eukaryoten einen nukleo-zytoplasmatischen Transportzyklus ein. Das Ziel der vorliegenden Arbeit bestand in der strukturellen sowie funktionellen Charakterisierung …
-
The Further Characterization of <i>Saccharomyces cerevisiae</i> Ribosomal Protein L30 and Its Interaction with the <i>RPL30</i> Transcript through Mutational Analysis, Circular Dichroism, and Fluorescence Methods
… RNAs in the ribosome, as well as in some small ribonucleoprotein particles such as components of the spliceosomal assembly. In order to study the interaction of L30 with its <em>RPL30</em> kinkturn, several mutations have been made in L30 protein at key positions in the protein/ RNA interface. …
-
Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
<p>In this thesis we first characterized neuronal functions for HPat/Pat1, a core component of RNA processing bodies or "P bodies". We show that <em>hpat</em> mutants exhibit a strong synaptic hyperplasia at the developing and acutely stimulated <em>Drosophila</em> larval neuromuscular junctions …