Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Ribonucleic acid (RNA)"”.
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Substitution of the Anticodon Loop of Yeast Tyrosine Transfer Ribonucleic Acid (Rna)
… residues 33-35 in the anticodon loop of yeast tRNA('Tyr) with any desired oligonucleotide have been developed. Half-molecules of tRNA('Tyr) from partial digestions with ribonuclease A or T(,1) were paired to create a gap in the anticodon loop. An oligonucleotide was inserted into the gap using …
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Eucaryotic Initiation Factor 4b of Wheat Germ Binds to the Translation Initiation Region of Satellite Tobacco Necrosis Virus Ribonucleic Acid (Rna)
… germ binds the intact, monocistronic, uncapped mRNA, STNV RNA, in nitrocellulose filter mediated binding assays with a K(,d) = 1 x 10('-7)M. EIF4B also binds the 5'-terminal 52 nucleotides of STNV {5'- ('32)P}RNA (i.e., the translation initiation site of STNV RNA) with the same efficiency as …
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
… occurring system of chemical modifications on ribonucleic acid (RNA) --
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A Predictive Model Which Uses Descriptors of RNA Secondary Structures Derived from Graph Theory.
<p>The secondary structures of ribonucleic acid (RNA) have been successfully modeled with graph-theoretic structures. Often, simple graphs are used to represent secondary RNA structures; however, in this research, a multigraph representation of RNA is used, in which vertices represent stems and …
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Eukaryotic RNA Polymerase II start site detection using artificial neural networks
An automated detection process for Eukaryotic ribonucleic acid (RNA) Polymerase II Promoter is presented in this dissertation. We employ an artificial neural network (ANN) in conjunction with features that were selected using an information-theoretic approach. Firstly an introduction is given where …
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Experiments on biomarker preservation
… experiments to determine the stability of ribonucleic acid (RNA) under early Mars-like conditions and groundtruthing experiments which complement ongoing analyses being conducted aboard the Sample Analysis at Mars (SAM) instrument in Gale Crater. The objective of this dissertation is to …
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Comparison of Stated Iron Concentrations Between Name Brand and Generic Children's Multivitamins
… within red blood cells, and to assist in Deoxyribonucleic acid (DNA) and Ribonucleic acid (RNA). With iron readily available in children's multivitamins, iron toxicity can become an issue when taking too many tablets. With two types of brands, generic and name brand, parents should be aware of …
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Analysis of RNA stability in forensic specimens
Ribonucleic acid (RNA) analysis presents a unique, novel opportunity to answer a wide range of questions in forensic science. The dynamicity of the transcriptome has led to it being suggested as a novel source of diagnostic information in forensic pathology. However, RNA is exceptionally labile. …
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Enhancing RNA Foundation Models via Secondary Structure Modelling
… of the code of life, yet their application to Ribonucleic Acid (RNA) is uniquely challenged by its functional dependence on complex structure. Modelling this intricate sequence-structure-function relationship represents a vital problem in computational biology. This thesis aims to resolve three …
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Development of an electronic aerosol atomisation system for generating three-dimensional (3D) cells in microencapsulations and microtissues characterisation
… showed stretching in phosphate bond of Deoxyribonucleic acid (DNA) and Ribonucleic acid (RNA) backbone, lipid and protein. The cells of HaCaT and ORL-48 microtissues were viable and they were characterised by different nucleus size. Replating experiment demonstrated that the cells in the …
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Investigating and Reprogramming RNA Folding with Molecular Probes
Ribonucleic acid (RNA) performs versatile, essential functions in all known organisms and viruses. These functions require the RNA to fold into specific secondary and tertiary structures, and in many cases to switch among multiple structural states. Predicting and experimentally determining RNA …
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… utilizing extracellular vesicles (EVs) is an alternative approach for obtaining insights into molecular landscapes of mCRC. Cancer-derived EVs play a critical role in cancer cell-to-cell communication and carry surface proteins and cell-specific cargos of nucleic acids. For this reason, we aimed …
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Generative Machine Learning Models for RNA Structure Prediction and Design
Ribonucleic acid (RNA) is a fundamental molecule in biology, central to the regulation and execution of life’s most essential processes. Its diverse roles range from encoding genetic information to catalyzing biochemical reactions. Beyond its modern biological functions, RNA is also believed to …
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Physiological studies with the experimental herbicide isouron
… processes examined were photosynthesis, protein, ribonucleic acid (RNA) and lipid synthesis. Relative incorporation of radiolabeled precursors was the parameter measured to assess herbicidal effects. Results indicate that isouron and its monomethylurea derivative possess similar herbicidal …
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Kelvin Probe Force Microscopy on Graphene Thin Films for Solar Cell and Biosensing Applications
… Graphene has been widely studied as an alternative to transparent conducting Indium Tin Oxide (ITO) electrodes in organic photovoltaics fabrication. Graphene platforms have also attracted interest in biological applications. However, large area graphene films are not yet widely …
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Elucidating the Impact of Endogenous Proteins on Lipid Nanoparticle Organ-Targeting Outcomes
Ribonucleic acid (RNA) biomolecules can be used for the prevention and treatment of various diseases by gene silencing, gene expression, and gene editing approaches. As RNA can be easily degraded by nucleases and does not readily cross the cell membrane to access the cytosol, where it is …
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Detection of Aneuploidy for Chromosomes 7 and 8 Using Fluorescence <i>In Situ</i> Hybridization in Patients with Aplastic Anemia and Sequencing of the Mitotic Checkpoint Gene hBUB1
… samples from patients with AA. In addition, ribonucleic acid (RNA) from all patient samples also underwent <em>hBUB1</em>-specific reverse transcription polymerase chain reaction (RT-PCR), followed by sequencing of the RT-PCR product. Statistical analyses were performed on FISH and sequencing …
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Prebiotic assembly and replication of nucleic acids
… for the origins of life, known as the "RNA world", relies on replication of ribonucleic acid (RNA) before the advent of protein enzymes and deoxyribonucleic acid (DNA). Essentially, the hypothesis relies on what some researchers believe is a parsimonious claim that RNA was the central …
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Analysis of soybean small RNA populations
Made available in DSpace on 2012-02-01T00:55:15Z (GMT). No. of bitstreams: 3 Win_Hlaing.pdf: 2806604 bytes, checksum: fd83d1b127a3edbf2c2b5d09055f19d1 (MD5) license.txt: 4057 bytes, checksum: bfab5ce9051b73addae93f75bad9bb47 (MD5) Win_Hlaing.docx: 2620656 bytes, checksum: …
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Evaluation of TP53 and IGHV clinical molecular prognostic testing for patients with Chronic Lymphocytic Leukaemia at Tygerberg Hospital
… from reverse transcription of extracted total ribonucleic acid (RNA), targeting exons 2 to 11 of the entire coding region. IGHV mutational status was assessed using a two-step approach, firstly clonality was determined via fragment analysis by capillary electrophoresis of framework regions of …
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