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Showing 1 to 2 of 2 for “"Ribonuclease Mutants"”.
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Degradation of 23S rRNA in Azithromycin-Treated Ribonuclease Mutants of <em>Escherichia coli</em>.
… particle. When exposed to azithromycin, several ribonucleases in wild-type <em>Escherichia coli</em> cells degrade antibiotic-bound 50S precursor particles. Presumably, cells expressing one or more mutated ribonucleases will degrade the antibiotic-bound precursor less efficiently, resulting in …
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An Investigation of Bacterial Ribonucleases as an Antibiotic Target
… 50S ribosomal subunits is processed by bacterial ribonucleases (RNases). RNases are also involved in the degradation and turnover of this RNA during times of stress, such as the presence of an antibiotic. This makes ribonucleases a potential target for novel antibiotics.</p><p>It was shown that …