Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Ribavirin"”.
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Neuroprotektiver Effekt von Ribavirin bei Borna Disease Virus infizierten Lewis-Ratten
… einen virostatischen Effekt des Guanosinanalogs Ribavirin gegenüber BDV. Ziel der vorliegenden Studie war es, den therapeutischen Nutzen einer intrathekalen Ribavirinapplikation bei akuter Bornascher Erkrankung (BD) im Rattenmodell zu untersuchen. Toxikologische und pharmakokinetische Studien …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… of care consists of pegylated interferon and ribavirin (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed mechanisms require RBV …
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Viruslastorientierte Interferon-a-2a-Therapie der chronischen Hepatitis-C-Infektion in Kombination mit Ribavirin und Amantadin
… Standard-Kombinationstherapie mit Interferon und Ribavirin erreichte eine Re-Therapie mit einer Dreifachkombination aus Interferon, Ribavirin und Amantadin eine hohe Rate an anhaltendem virologischen Response.
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Evaluation kognitiver Störungen bei Patienten mit chronischer Hepatitis C unter Therapie mit Interferon-alpha und Ribavirin
… oder in Kombination mit dem Guaninanalogon Ribavirin wurden auf häufig geschilderte neurotoxische Nebenwirkungen, insbesondere kognitive Störungen sowie die Entwicklung von Symptomen eines depressiven Syndromes objektiv untersucht. Zur Evaluation der geschilderten Beschwerden dienten …
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Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
… Kentsis and colleagues10 demonstrated that ribavirin disrupts subcellular organization of eIF4E and suppresses eIF4E-mediated oncogenic transformation of murine cells and tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma. These findings suggest a specific and …
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The Use of Healing Touch in Adults with Hepatitis C Virus Receiving Interferon and Ribavirin: A Pilot Study
… for HCV is a combination of interferon and ribavirin; however, as many as 92% of patients experienced fatigue as a side effect. The severity of this symptom caused some patients to skip dosages or even stop the required medication regimen before it was completed. The primary purpose of this …
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Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… with pegylated interferon a (PEG-IFN) and ribavirin is recommended. The sustained virological response rate six months after stop of treatment (SVR) is about > 55% in treatment naive patients. Because the treatment with PEG-IFN plus ribavirin is 6 to 12 months with a large number of adverse …
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Novel acyclic nucleotide phosphonates against RNA viruses
… such as HIV/AIDS and hepatitis while the drug ribavirin is one of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large and unmet need for anti-RNA viral treatments has prompted this study into the design and synthesis of a range …
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Modulation of the immune response by current and novel treatments for hepatitis C virus
… many years, the exact mechanisms of actions of ribavirin are poorly understood. These current treatments are poorly tolerated by many and therefore newer and more effective treatments are being investigated.<br/>This thesis investigated how current and novel treatments were able to modulate the …
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Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
… kinetics, sensitivity to the antiviral Ribavirin, and attenuation in an AG129 mouse model were evaluated. 17D-204 virus is known to have reduced genetic diversity, increased multiplication kinetics in A549 cells, increased resistance to Ribavirin, and is attenuated in AG129 mice when …
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Virus elimination from Actinidia germplasm
… hydrochloride, 5-azacytidine, oseltamivir, ribavirin, 2-thiouracil, and vidarabine) against AMV, ASGV, AVX, CLBV-a, and CMV in N. occidentalis shoot tip cultures cultures was determined. Only ribavirin (20mg/L) and ribavirin (10mg/L) combined with quercetin (10mg/L) had a significant effect …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock copolymers (polyethylene glycol-polypropylene glycol-polyethylene glycol) should allow increased drug …
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A Decade of Hepatitis C at the UCT/GSH Liver Clinic in the Pre-DAA era
… (GSH) in the Pegylated interferon (Peg-IFN) and Ribavirin (RBV) management era. Methods Patients with chronic HCV attending GSH Liver Clinic from 2002 to 2014, were included, in the analysis. Relevant data were extracted from a registry and existing clinical records accessed. Two brands of …
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Human Parainfluenza Virus 3: Genetic Diversity, Virulence and Antiviral Susceptibility
… applied to three potential inhibitors of HPIV3: ribavirin, favipiravir and zanamivir. The results showed that clinical strains were at least as susceptible to ribavirin and favipiravir as the laboratory reference strain and significantly more susceptible to zanamivir. This indicates that further …
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Hepatitis C virus infection in patients receiving opiate substitution therapy in Sweden.
… We evaluated feasibility of peginterferon/ribavirin based HCV treatment, in the same cohort, with special attention to psychiatric status and health related quality of life (HRQoL). In a register based study we evaluated liver related mortality in relation to OST exposure in heroin users …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.
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Peripheral Generation of Regulatory T Cells in Health and Disease
… after anti-viral treatment with Interferon and Ribavirin. Interestingly, increase in anti-viral immune responses after Treg depletion was not seen in patients who were successfully treated with interferon and ribavirin. These results suggest that anti-viral therapy may be acting by modulating …
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PRODUCTION OF VIRUS-FREE ORCHIDS VIA TISSUE CULTURE TECHNIQUES
… virus-free plants regardless of the presence of ribavirin. A highly sensitive diagnostic test for CyMV was also developed based on the polymerase chain reaction. As little as 1 fg of viral RNA (about 200 target copies) or 10 fg of purified virus (approximately 130 viral particles) could be …
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Application of thermodynamic principles in biocatalytic synthesis of novel nucleoside analogues
… an unexpected N7-xanthosine and various ribavirin derivates were synthesized and purified in milligram yields. The cytotoxicity in human cell lines was evaluated for selected examples. In conclusion, it is confirmed that thermophilic nucleoside phosphorylases exhibit an impressive …
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Die Rolle des Interferon-g bei der Hemmung der Replikation des Hepatitis-C-Virus
… Kombinationsbehandlung aus Peg-Interferon-a und Ribavirin. Allerdings kann mit diesen Medikamenten nur ein Teil der Patienten von der Erkrankung geheilt werden. Die Erforschung des HCV-Genoms, der viralen Replikation, sowie der Wirkmechanismen der eingesetzten Medikamente war lange Zeit durch das …
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