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Showing 1 to 20 of 30 for “"Ribavirin"”.

  1. Neuroprotektiver Effekt von Ribavirin bei Borna Disease Virus infizierten Lewis-Ratten

    Schlaberg, RobertUniversität Würzburg

    … einen virostatischen Effekt des Guanosinanalogs Ribavirin gegenüber BDV. Ziel der vorliegenden Studie war es, den therapeutischen Nutzen einer intrathekalen Ribavirinapplikation bei akuter Bornascher Erkrankung (BD) im Rattenmodell zu untersuchen. Toxikologische und pharmakokinetische Studien …

    wurz-thes Repository record

  2. Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection

    Ibarra, Kristie Dawn2011

    … of care consists of pegylated interferon and ribavirin (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed mechanisms require RBV …

    utswmed Repository record

  3. Evaluation kognitiver Störungen bei Patienten mit chronischer Hepatitis C unter Therapie mit Interferon-alpha und Ribavirin

    Wißmann, SaskiaUniversität Würzburg

    … oder in Kombination mit dem Guaninanalogon Ribavirin wurden auf häufig geschilderte neurotoxische Nebenwirkungen, insbesondere kognitive Störungen sowie die Entwicklung von Symptomen eines depressiven Syndromes objektiv untersucht. Zur Evaluation der geschilderten Beschwerden dienten …

    wurz-thes Repository record

  4. Viruslastorientierte Interferon-a-2a-Therapie der chronischen Hepatitis-C-Infektion in Kombination mit Ribavirin und Amantadin

    Lingenauber, ChristophUniversität Würzburg

    … Standard-Kombinationstherapie mit Interferon und Ribavirin erreichte eine Re-Therapie mit einer Dreifachkombination aus Interferon, Ribavirin und Amantadin eine hohe Rate an anhaltendem virologischen Response.

    wurz-thes Repository record

  5. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Waldenström, Jesper2020

    … until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. Ribavirin is still used in the most difficult-to cure patients. This thesis evaluates host genetic variations in inosine triphosphate pyrophosphatase (ITPA) and interferon-λ4 (IFNL4) in …

    goteborg Repository record

  6. Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function

    Hsiung, Ying-Fan2010

    … Kentsis and colleagues10 demonstrated that ribavirin disrupts subcellular organization of eIF4E and suppresses eIF4E-mediated oncogenic transformation of murine cells and tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma. These findings suggest a specific and …

    utswmed Repository record

  7. The Use of Healing Touch in Adults with Hepatitis C Virus Receiving Interferon and Ribavirin: A Pilot Study

    Taylor, Margaret Ann, PhD, MSN, CNS, HTCP/I2021

    … for HCV is a combination of interferon and ribavirin; however, as many as 92% of patients experienced fatigue as a side effect. The severity of this symptom caused some patients to skip dosages or even stop the required medication regimen before it was completed. The primary purpose of this …

    usd-thes Repository record

  8. Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin

    Cao, Hua

    … with pegylated interferon a (PEG-IFN) and ribavirin is recommended. The sustained virological response rate six months after stop of treatment (SVR) is about > 55% in treatment naive patients. Because the treatment with PEG-IFN plus ribavirin is 6 to 12 months with a large number of adverse …

    freiburg-diss Repository record

  9. Modifizierte Therapiestrategien in der Kombinationstherapie mit pegyliertem Interferon alpha-2a (PEG-IFN alpha-2a) und einer einmal täglichen Fixdosis von Ribavirin bei HCV-infizierten Drogenabhängigen unter Substitutionsbehandlung

    Waizmann, Michael2010

    … alfa-2a und einer singulären Tagesdosis Ribavirin zur Behandlung der chronischen Hepatitis C bei 49 intravenöse Drogengebrauern (IVDAs), die an einem Substitutionsprogramm in einer suchtmedizinischen Spezialambulanz teilnahmen. Die Patienten erhielten außerdem eine prophylaktische …

    fu-berlin Repository record

  10. Novel acyclic nucleotide phosphonates against RNA viruses

    Bowden, Gregory DavidDepartment of Chemistry2012

    … such as HIV/AIDS and hepatitis while the drug ribavirin is one of the only drugs available for the treatment of RNA-viral infections which mainly affect the developing world. The large and unmet need for anti-RNA viral treatments has prompted this study into the design and synthesis of a range …

    cape-town Repository record

  11. Modulation of the immune response by current and novel treatments for hepatitis C virus

    Barker, Sophie JoannaUniversity of Southampton2011

    … many years, the exact mechanisms of actions of ribavirin are poorly understood. These current treatments are poorly tolerated by many and therefore newer and more effective treatments are being investigated.<br/>This thesis investigated how current and novel treatments were able to modulate the …

    soton Repository record

  12. Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D

    Strother, Ashley EThe University of Texas Medical Branch at Galveston2022

    … kinetics, sensitivity to the antiviral Ribavirin, and attenuation in an AG129 mouse model were evaluated. 17D-204 virus is known to have reduced genetic diversity, increased multiplication kinetics in A549 cells, increased resistance to Ribavirin, and is attenuated in AG129 mice when …

    utmb Repository record

  13. Virus elimination from Actinidia germplasm

    Cowell, SarahResearchSpace@Auckland2013

    … hydrochloride, 5-azacytidine, oseltamivir, ribavirin, 2-thiouracil, and vidarabine) against AMV, ASGV, AVX, CLBV-a, and CMV in N. occidentalis shoot tip cultures cultures was determined. Only ribavirin (20mg/L) and ribavirin (10mg/L) combined with quercetin (10mg/L) had a significant effect …

    auckland-ms Repository record

  14. Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules

    Vasa, Dipy Madhukar2018

    … levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock copolymers (polyethylene glycol-polypropylene glycol-polyethylene glycol) should allow increased drug …

    duquesne Repository record

  15. A Decade of Hepatitis C at the UCT/GSH Liver Clinic in the Pre-DAA era

    Nordien, RozeenaDepartment of Medicine2019

    … (GSH) in the Pegylated interferon (Peg-IFN) and Ribavirin (RBV) management era. Methods Patients with chronic HCV attending GSH Liver Clinic from 2002 to 2014, were included, in the analysis. Relevant data were extracted from a registry and existing clinical records accessed. Two brands of …

    cape-town Repository record

  16. Prävalenz und klinische Bedeutung von organspezifischen und nicht-organspezifischen Autoantikörpern bei Patienten mit Hepatitis-C-Infektion

    Stolte, ChristianPublikationsserver der RWTH Aachen University2004

    … combination therapy with interferon-( and ribavirin in 65 patients. RESULTS: In our study, positivity for autoantibodies was associated with higher alanine aminotransferase levels and higher mean values for HCV-RNA (p < 0.01). Furthermore, negativity for non-organ-specific autoantibodies, …

    aachen Repository record

  17. Human Parainfluenza Virus 3: Genetic Diversity, Virulence and Antiviral Susceptibility

    Smielewska, Anna AlexandraUniversity of Cambridge2019

    … applied to three potential inhibitors of HPIV3: ribavirin, favipiravir and zanamivir. The results showed that clinical strains were at least as susceptible to ribavirin and favipiravir as the laboratory reference strain and significantly more susceptible to zanamivir. This indicates that further …

    cambridge Repository record

  18. Hepatitis C virus infection in patients receiving opiate substitution therapy in Sweden.

    Jerkeman, AnnaInfectious Diseases Research Unit2014

    … We evaluated feasibility of peginterferon/ribavirin based HCV treatment, in the same cohort, with special attention to psychiatric status and health related quality of life (HRQoL). In a register based study we evaluated liver related mortality in relation to OST exposure in heroin users …

    lund Repository record

  19. Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение

    Ivanova, Irina, Иванова, ИринаMedical University of Varna2026

    … was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.

    varna Repository record

  20. Peripheral Generation of Regulatory T Cells in Health and Disease

    Pillai, Vinodh2010

    … after anti-viral treatment with Interferon and Ribavirin. Interestingly, increase in anti-viral immune responses after Treg depletion was not seen in patients who were successfully treated with interferon and ribavirin. These results suggest that anti-viral therapy may be acting by modulating …

    utswmed Repository record

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