Global ETD Search
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Showing 1 to 2 of 2 for “"Rhodanines"”.
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Targeting Tau Aggregation for the Diagnosis and Treatment of Alzheimer’s Disease
… phenothiazines, triarylmethines, and rhodanines. A study of these compound families reveals polarizability as the key molecular characteristic for generating inhibitory potency. Further analysis with the most potent non-cyclic cyanine revealed the stabilization of a soluble, …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
The emergence of resistance to cancer treatments through methods that generate cell death by inducing DNA damage, such as chemotherapeutics and radiation therapy, is a major obstacle to overcoming the disease. Resistance occurs through the repair of single strand DNA breaks by the poly(ADP-ribose) …