Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"RhoGTPases"”.
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… are the small GTPases of the Rho family. Small RhoGTPases are regulated by GTPase exchange factors (GEF) and GTPase activating proteins (GAP), which can switch GTPases into "on or off" states, respectively. It is thought that GEFs and GAPs function as intracellular mediators between …
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Microgravity Exerts an Age-Dependent Effect on Cardiovascular Progenitor Cell Development
… the expression of mechanosensitive small RhoGTPases. Given the effect of these molecules on intracellular calcium levels, we evaluated changes in non-canonical Wnt/calcium signaling. ISS-cultured CPCs exhibited elevated levels of calcium handling and signaling </p> <p>genes, which …
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Kalirin : novel role in osteocyte function
… exchange factor (GEF) protein that activates the RhoGTPases. Recently, we found that 14 week old female Kalirin knockout (Kal-KO) mice exhibit a 45% decrease in trabecular bone density and have significantly lower cortical area, perimeter, thickness and polar cross-sectional moment of inertia …
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An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function
… These two pieces of data suggested that the RhoGTPases, Rac and RhoA might be differentially controlled within spread platelets. This was confirmed as platelets spread on oxLDL and fibrinogen in the presence of PGI2 showed elevated levels of Rac activity, whilst RhoA activity was …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
Rho GTPases and their regulators such as guanosine exchange factors (GEFs) and GTPase activating proteins (GAPs) represent an important class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis …