Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RhoGTPase"”.
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Organizing morphogenesis: Mechanisms of actomyosin patterning by RhoGTPase signaling
Morphogenesis is an astonishing orchestration of molecules, cells and tissues, of signaling and mechanics, across space and time. How are its components choreographed across scales? This thesis investigates this question in the context of Drosophila ventral furrow formation, a well-established, …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
… screening with yeast two-hybrid identified a RhoGTPase, Rif, as a novel interacting protein for FARP1. To investigate how Rif/FARP1 interaction is involved in Plexin signaling, I determined the crystal structure of Rif-bound FARP1. This complex structure explains the functional roles that …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
… revealed that merlin may regulate members of the RhoGTPase
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Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
… of P-Rex1, adding to our understanding of how RhoGTPase GEFs function in cancer.
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A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
… This is the first in vivo evidence that the RhoGTPase CDC-42 regulates invadopodia formation through WSP-1. RabGTPase GDI-1 is a novel regulator of the unique membrane compartment required for invadopodia formation. CDC-42 and GDI-1 both function downstream of an unknown cue secreted by the …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… peripheral nerves by attenuating TNF-α-mediated, RhoGTPase-dependent secretion of chemokines by the peripheral nerve vascular endothelial cells (PNVECs) that form the blood-nerve barrier. Experiments using PNVECs are lacking, and there is no commercially available cell line. We formed a novel, …
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Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
… increased levels of activated Rac1, a RhoGTPase which regulates HSC engraftment capacity, compared to PTPRS+/+ BM cells. PTPRS-/- BM cells displayed significantly increased transendothelial migration capacity and cobblestone area forming cells (CAFC), consistent with increased Rac1 …
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S100A4 regulation and function
S100A4 is a calcium binding and tumor associated protein. Despite its critical roles in multiple aspects of cancer progression and non-malignant disease development, the investigations on the regulation of S100A4 are limited. This dissertation focuses on exploring the mechanisms of S100A4 …