Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RhoGEF"”.
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… activation of the protein. The RGS subfamily of RhoGEFs (RGS-RhoGEFs) act as direct mediators of RhoA activation in response to stimulation of the heterotrimeric G12 and G13 proteins by hormone receptors. RhoGEFs usually bind most tightly to the nucleotide free form of RhoA, which represents the …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… by Rho guanine nucleotide exchange factors (RhoGEFs) play an important role in this process. The present thesis investigates the mechanisms that control activation and specificity of the GTPase Rho1 by DRhoGEF2 during morphogenesis of the Drosophila embryonic epidermis. DRhoGEF2 is the …
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
… Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate either Rac or Rho GTPases, respectively. The RhoGEF1 domain and the Rac pathway are required for axon guidance in neuronal development, while the RhoGEF2 domain is involved in the control of locomotion, …
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Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… Colchicine incubation has been shown to release RhoGEF, a RhoA activator, and resulted in increased tonic force and MLC-p which were both inhibited by a ROK inhibitor.Additionally, KC1-stimulation appeared to activate MAPK and ROK pathways, while stretch alone activated a yet undetermined …
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Molecular mechanisms of mammalian cell survival and differentiation
… understood. In Chapter 2, I identified XPLN, a RhoGEF, as an endogenous inhibitor of mTORC2 kinase activity towards Akt. Furthermore, I showed that the GEF activity of XPLN is dispensable for its regulation of mTORC2 and Akt, whereas an N-terminal 125-amino acid fragment of XPLN is both …
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Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>
The gene pebble (pbl) encodes a Rho GEF required for the migration of mesoderm cells during Drosophila gastrulation. The spreading of mesoderm cells is controlled by the FGF signalling pathway acting through the FGF receptor Heartless (Htl). Pbl represents an important downstream component of this …
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Regulation of rho guanine nucleotide exchange factors through lipid binding and phosphorylation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
… containing Dbl-homology (DH) domain, called RhoGEFs, which are known for conserved DH-PH domain structures. While the DH domain is responsible for GEF activity, the function of the PH domain in RhoGEFs is not well-understood. In Chapter 4, I have investigated the role of phosphoinositide …