Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RhoGDI"”.
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Investigating the Functional Interaction between RhoGDI Family Proteins and Activated Cdc42 associated-kinase (ACK)
… yeast-2-hybrid screen in the lab identified RhoGDI-3 as an interacting partner for ACK. RhoGDI-3 is a member of RhoGDI family of proteins, which are negative regulators that maintains Rho-family GTPases in the inactive GDP-bound state and sequesters them in the cytosol. RhoGDIs have also been …
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Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase
… Rac1, RhoA and Cdc42 share a common inhibitor, RhoGDI. It is only recently becoming clear how upstream signals cause the selective release of individual Rho GTPases from RhoGDI. For example, our laboratory showed that diacylglycerol kinase zeta (DGKz), which converts diacylglycerol (DAG) to …
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Reconstitution Of Rho Gtpase Interactions At The Membrane
… Rho guanine nucleotide-dissociation inhibitor (RhoGDI). The mechanism by which the Rho GTPases move between distinct locations in the cell, and in particular, how they are able to cycle on and off between different membranes, has been a challenging question. I have set out to begin to define …
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Control of protein adsorption, cell morphology and intracellular signal transduction using self-assembled monolayers of alkylthiolates on gold
… and shown to be surface chemistry-dependent RhoGDI levels and intracellular localization were also shown to be surface-chemistry dependent Cells cultured on -CH3 terminated SAMs, which normally exhibit a cultured on -CH3 terminated SAMs, which normally exhibit a low growth phenotype, were …