Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RhoB"”.
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Biophysical and computational insights into the stability of RhoB and its cancer-associated variants
RhoB is a small GTPase, part of the Rho family of the Ras superfamily of small G proteins, that act as cellular signalling switches. RhoB is involved in regulating the cytoskeleton, angiogenesis, cell death, endosome trafficking and DNA damage repair. Unlike other small GTPases such as K-Ras, RhoA …
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Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
… associated with the invasive phenotype such as RHOB and DKK1, and networks associated with cell motility such as integrinlinked kinase signaling, and focal adhesion kinase signaling. AREG was also found to modulate WNT and Notch signaling in SUM-149 cells. In an additional microarray study, …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… littermates. Furthermore, we report that total RhoB is expressed in the soma and nucleus of WT motor neurons; however, RhoB shows a marked redistribution to neuronal processes in end-stage mice harboring the G93A SOD1 mutation. These data underscore the importance of Rho family GTPases in …
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Investigating the Functional Interaction between RhoGDI Family Proteins and Activated Cdc42 associated-kinase (ACK)
… of these target proteins, including RhoA, RhoB, Rac1 and RhoH, which are known to be involved in cell proliferation and migration. Aberrant activation of these target protein is frequently observed in cancer, suggesting a role for RhoGDI to drive ACK oncogenicity.