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Showing 1 to 20 of 104 for “"RhoA"”.
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
RhoA plays a key role in regulation of the actin cytoskeleton, cell migration and cell shape. Rho GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… efficiently inhibit these "undruggable" targets. RhoA is a member of the Rho family within the Ras superfamily of small GTPases and is a major regulator of cytoskeletal remodelling, cell migration and proliferation. It is found overexpressed, overactivated or mutated (eg. RhoA G17V) in many …
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Genetic Analysis Of Rhoa Signaling During Epithelial Morphogenesis In Drosophila
… disc morphogenesis. These include members of the RhoA signaling pathway and the product of the Stubble-stubbloid (Sb-sbd) locus, a transmembrane serine protease. Mutations in the Sb-sbd gene interact genetically with the members of the RhoA signaling pathway, however the nature of the relationship …
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Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase
… three most well characterized Rho GTPases, Rac1, RhoA and Cdc42 share a common inhibitor, RhoGDI. It is only recently becoming clear how upstream signals cause the selective release of individual Rho GTPases from RhoGDI. For example, our laboratory showed that diacylglycerol kinase zeta (DGKz), …
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RhoA and Rac1 prenylation: Effects on serine/threonine signaling for actin polymerization
RhoA and Rac1 are small guanosine triphosphates (GTPases) that regulate cytoskeletal rearrangements, cell polarity and axon guidance and signaling pathways. Alteration of the subcellular localization or activation of Rho GTPases is implicated in several neurological conditions. Rho GTPases are …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… when bound to guanosine diphosphate (GDP). RhoA, a member of the Rho family GTPases, participates in the formation of focal adhesions, retraction of neuron processes in response to injury or insult and growth cone collapse. Rac1, another Rho GTPase, is implicated in regulating cell …
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Einfluss der GTPase RhoA auf die axonale Regeneration und die Erholung der Funktion von Neuronen in organotypischen Kulturen
… spezifische Inaktivierung eines ihrer Vertreter, RhoA, durch das C3-Fusionstoxin aus C. botulinum hat in einer in vivo Studie zur Regeneration von Neuriten geführt. Dieser Effekt sollte in der vorliegenden Arbeit in organotypischen Kokulturen von Cortex und Striatum neonataler Ratten untersucht …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
… cellular effects at least in part by inhibiting RhoA GTPase. However, what links these GTPases with the EphA4 receptor remained unknown.</p> <p>In an attempt to investigate involvement of the Src-like tyrosine kinase p59fyn in EphA4 signaling, a series of experiments was planned using the …
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Mapping And Characterization Of 18-5 And 12-5, Genes Which Potentially Link The Rhoa Signaling Pathway To The Ecdysone Response
… hormone 20-hydroxyecdysone (ecdysone) and the RhoA GTPase signaling pathway. Recent evidence suggests that these pathways act cooperatively to control imaginal disc morphogenesis. Thus, leg imaginal disc morphogenesis is an excellent system in which to study the interaction of steroid hormone …
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… blocker, trifluoperazine. Since, -30% of RhoA is colocalized with caveolin basally, these data suggest a novel model for Ca<sup>2+</sup>-activated Ca<sup>2+</sup>-sensitization, elicited by KC1 contraction, that involves Ca<sup>2</sup>+/cam dependent ROK translocation to caveolae and …
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… of the PH domain from p190RhoGEF bound to either RhoA•GTP or Rac1•GTP. The interfaces between activated Rac1 or RhoA with the PH domain utilize the same hydrophobic surface on the PH domain. Similar to RhoA, activated Rac1 interacts with the PH domain via its effector-binding surface albeit …
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Fluid Flow Forces Regulate Fibrous Extracellular Matrix Protein Expression and Deposition Via A Rhoa/Rho Kinase Dependent Pathway During Atrioventricular Valve Development
… mechanism was carried out by manipulating the RhoA/Rho kinase pathway. From our experiments, RhoA/Rho kinase pathway was shown to bridge the mechanical forces and the biological responses from the AV cushions with increases of fibrous proteins expression and correlated changes of the cushion …
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Die Bedeutung von Rho-Proteinen für Migration, Zellkontaktbildung und Aktinfilamentdifferenzierung in Endothelzellen
… wichtige Vertreter dieser Gruppe: Rac, CDC42 und RhoA. Es wurde die Prenylierung von Proteinen und damit auch die Prenylierung von Rho-Proteinen durch den HMG-CoA-Reduktase-Hemmer Lovastatin unterdrückt. In einer zweiten Versuchsserie wurden alle Rho-Proteine unselektiv durch Toxin-B, einem Toxin …
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CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
… cellular intrinsic contraction by upregulating RhoA signaling and downregulating of Rac1 activity. CD151 balances RhoA and Rac1 activities and stabilizes the membrane-cytoskeleton connection. In the absence of CD151 expression, the inhibition of RhoA signaling axis enhances the diminished …
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The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer
… cell transforming gene 1 (Net1) is a RhoA guanine nucleotide exchange factor that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… are stimulated by the GTPases Arf1 and RhoA, we investigated in the following, if PLD is involved in the regulation of PIP2 synthesis by these GTPases. Both PLD1- and PLD2-induced PIP2 synthesis was completely blocked by coexpression of catalytically inactive Arf1 T31N. Reversely, the …
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Molekulare Analyse der Yersinien-Wirtszell Interaktion
… der Rho-GTPasen zu denen u.a. auch die Proteine RhoA und Cdc42 gehören. Diese kleinen G-Proteine sind in komplexer und in noch unvollkommen verstandener Weise an der Regulation vielfältiger Zellfunktionen beteiligt. Es konnte gezeigt werden, dass YopO neben Rac1 auch mit RhoA, nicht jedoch mit …
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Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
… how lipids elicit stiffening, we focused on RhoA and its association with RhoGDI1, which maintains RhoA inactive. We show that RhoA and RhoGDI1 are required for palmitic acid-induced stiffening. These findings point to RhoGDI1 as a target for the development of studies into WD-induced …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… DDR1 activation and expression, increased Vav2-RhoA activity, and increased stress fibre formation in Ddr1+/+ but not Ddr1-/- VSMCs. RhoA activation increased DDR1 expression and activity independent of ligand, whereas inhibition of RhoA and actomyosin contractility were inhibitory. RUNX2 …
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