Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Rho1"”.
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
… two Rho subfamilies have only one member, Rho1 and Cdc42, which allows for straightforward loss-of-function analysis, in vivo. To determine the role of Rho1 and Cdc42 in Drosophila epithelia, we used mosaic clonal analysis and targeted RNA interference expression to perform loss-of-function …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… <i>A. fumigatus</i>. One such protein <i>Af</i>Rho1 is a Rho GTPase, plays essential roles in fungal physiology and cell wall organization. In this research, I combined X-ray crystallography and fragment-based small molecule screening by BLI (Biolayer interferometry) to investigate the …
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Notopleural Mutations Enhance Defects In Imaginal Disc Epithelial Morphogenesis And Macrochete Elongation Associated With Mutations in the Stubble-Stubbloid Locus
… genetic interactions between Stubble and the Rho1 signaling pathway suggest Stubble influences actin cytoskeleton dynamics in developing imaginal discs through interactions with the Rho1 pathway. This work will discuss a genetic screen conducted to further investigate the role of Stubble in …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… control activation and specificity of the GTPase Rho1 by DRhoGEF2 during morphogenesis of the Drosophila embryonic epidermis. DRhoGEF2 is the Drosophila ortholog of the human RhoGEFs, LARG (Leukemia-associated RhoGEF), PDZ-RhoGEF and p115 RhoGEFs. In addition to a catalytic module, DRhoGEF2 …
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Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
… spezifisch RHO4, und NCU00668 wirkt als RHO1-spezifischer GEF, der möglicherweise durch eine intramolekulare Wechselwirkung autoreguliert wird. Weiterhin wird gezeigt, dass CDC24 ein essentielles Protein ist, das für die Etablierung und die Aufrechterhaltung polaren Wachstums in N. crassa …
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Cigarette Smoke Exposure in Drosophila Reveals Wnt-Mediated Remodeling of Airway Structure and Systemic Physiology
… Wnt signaling mediated by the Rho GTPases Rho1 and Rac1. Activation of canonical Wnt signaling through β-catenin overexpression significantly alleviated smoke-induced defects, improving developmental rates, survival, locomotor performance, and metabolic balance. At the cellular level, …
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Inactivation of Tor Proteins Affects the Dynamics of Endocytic Proteins in Early Stage of Endocytosis
<p>Tor2 is an activator of the Rom2/Rho1 pathway that regulates α-factor internalization. Since the recruitment of endocytic proteins such as actin binding proteins and the amphiphysins precedes the internalization of α-factor, I hypothesized that loss of Tor function leads to an alteration in the …
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Regulation of Morphogenetic Events in Saccharomyces cerevisiae
… to weaken the cell wall sufficiently to bud. Rho1 activation by Rom2 occurred at around the time of bud emergence, perhaps in response to local cell wall weakening. This report reveals regulatory mechanisms underlying the morphogenetic events in the budding yeast.</p>
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
… an increase and a decrease in the activity of Rho1-Myosin-II pathway enhances and decreases multi- layering of α-spec mutant FCs, respectively. Similarly, higher Myosin-II activity enhances the multi-layering phenotype of FCs that lack Integrins. Furthermore, the role of α-Spec in the proper …