Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Rho-kinase"”.
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Discovery of novel highly selective Rho kinase (ROCK) inhibitory peptides and evaluation of their biological activities
Rho/Rho kinase pathway is a major regulator of actin cytoskeletal dynamics generation of actin-myosin contractility and has been linked to many human diseases including heart failure, hypertension, PAH, atherosclerosis, renal failure, glaucoma, and cancer. This makes ROCK as promising potential …
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The Functional Roles of Rho-Kinase and Matrix Metalloproteinases in Regulating Corneal Stromal Cell Mechanics in 3-D Collagen Matrices
The file named "ZHOU-DISSERTATION-2013.pdf" is the primary dissertation file. Eleven (11) supplemental movie files are also available.
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Fluid Flow Forces Regulate Fibrous Extracellular Matrix Protein Expression and Deposition Via A Rhoa/Rho Kinase Dependent Pathway During Atrioventricular Valve Development
… mechanism was carried out by manipulating the RhoA/Rho kinase pathway. From our experiments, RhoA/Rho kinase pathway was shown to bridge the mechanical forces and the biological responses from the AV cushions with increases of fibrous proteins expression and correlated changes of the cushion …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PIP-5-kinase. Overexpression of PLD isoforms in HEK-293 cells led to an increase in …
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Lysophospholipide als Modulatoren proinflammatorischer und thrombogener Signalwege in humanen Endothelzellen und Thrombozyten
… Membran-gebundene LPA-Rezeptoren - die GTPase Rho und deren Effektor- Molekül Rho-Kinase aktivieren. Rho-Kinase hemmt die Myosin Leichtketten Phosphatase, wodurch es zum Anstieg der Myosin Leichtketten Phosphorylierung kommt. Myosin Leichtketten Phosphorylierung führt (i) zur Kontraktion von …
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Die Angiotensin II induzierte Vasokonstriktion isolierter Arterien und deren Beeinflussung durch OxLDL
… fanden sich jedoch viele Hinweise auf eine Rho-Kinase vermittelte Aktivitätsmodulierung der Myosin-Leichtketten-Phosphastase. Die Beteiligung der Rho-Kinase an der Angiotensin II induzierten Vasokonstriktion konnte durch den Einsatz des Rho-Kinase Hemmers Y27632 gezeigt werde. Nach …
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SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION
… activation in the circulation. It was noted that Rho-kinase inhibitor reduced sepsis-induced pulmonary recruitment of neutrophils and tissue injury via regulation of CXC chemokines formation in the lung. Moreover, inhibition of Rho-kinase signaling decreased sepsis-induced T-cell apoptosis as well …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… and PAR2 agonists stimulated PI hydrolysis and Rho kinase activity and inhibited cAMP formation. PAR1-stimulated PI hydrolysis was abolished in cells expressing Gαq minigene, but was not affected in cells expressing Gαi minigene or in cells treated with pertussis toxin (PTx). PAR2-stimulated PI …
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The role of prostaglandins, nitric oxide and oxygen in the ductus arteriosi of the pre-term chicken embryo (Gallus domesticus).
… ROS, Kv channels, L-type Ca2+ channels, and the Rho kinase pathway. Longer exposure to high oxygen generates increased oxygen induced constriction of the day 19 DA that may be mediated through the Rho kinase pathway.
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Investigation of Cell Morphology and Cell-Induced 3-D Matrix Reorganization
… sub-cellular level. To specifically study how Rho and Rac regulate sub-cellular mechanical behavior, cells were plated inside 3-D matrices and incubated with activators and/or inhibitors of Rho and Rac and 3-D optical section images were collected simultaneously. Cell morphology, collagen …
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Untersuchungen zur Wirkung des Pasteurella multocida Toxins auf die endotheliale Barrierefunktion in vitro
… endothelialen Zytoskeletts wurden die Zellen mit Rhodamin Phalloidin gefärbt und im Fluoreszenzmikroskop analysiert. Mit Hilfe spezifischer Hemmstoffe, die teilweise in die Zellen mikroinjiziert wurden, sowie der biochemischen Messung von Enzymaktivitäten bzw. Phosphorylierung, erhielten wir …
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ROCK2 Polymorphism in Patients with Vasospastic Angina
… to vasoconstrictor stimuli the small GTPase RhoA and its downstream effector, ROCK/Rho-kinase, are associated with hypercontraction of the vascular smooth muscle of coronary arteries through augmentation of myosin light chain phosphorylation and Ca2+ sensitization. Expression of …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… (LFA-1), matrix metalloproteinases (MMPs) and Rho-kinase as well as nuclear factor of activated T-cell (NFAT) signaling in AP. We found that TLR4 but not TLR2 plays a role in AP. LFA-1 adhesive mechanisms play a role in tissue damage and leukocyte recruitment but not trypsinogen activation. …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… The role of p38 mitogen-activated protein kinase and Rho-kinase signalling was next examined by use of specific antagonists. Blocking p38 mitogen-activated protein kinase and Rho-kinase activity markedly decreased radiation-induced leukocyte and platelet recruitment in the colonic …
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The influence of oxidised low density lipoproteins on platelet activation
… that lead to a Ca²⁺ dependent activation of MLC kinase (MLCK) and the Rho kinase dependent inhibition of MLC phosphatase (MLCP). OxLDL induced platelet shape change correlated with MLCSer¹⁹ phosphorylation. OxLDL also stimulated a tyrosine kinase pathway involving the proteins Syk and PLCγ2, …
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Mechanisms of impaired red blood cell ATP release in older adults: implications for altered vascular control with age
… intact with age; and (iii) that systemic Rho-kinase inhibition via administration of fasudil improves the age-related impairments in vascular control and circulating ATP during systemic hypoxia and exercise, which may be related to enhanced RBC ATP release and NO bioavailability. These …
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MOLECULAR AND FUNCTIONAL CHARACTERISATION OF THE ROLE OF HYDROGEN SULPHIDE IN SEXUAL MEDICINE
… to result from its attenuating effect on the RhoA/Rho-Kinase contractile pathway. In this system, H2S was shown to downregulate the level of RhoA and Rho Kinase II (ROCK II) proteins which may have direct implication on corporal smooth muscle tone. In summary, findings from this thesis work …
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Structural and functional investigation of the trabecular outflow pathway
… the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and associated morphological changes in normal human eyes and laser-induced ocular hypertensive …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… The main sensitizing pathways, involving protein kinase C (PKC) and Rho-kinase, are established in the newborn tissue. The effects of PKC activation on muscarinic receptor-induced responses differ in newborn and adult tissue. The muscarinic receptor-induced response of the newborn is abolished in …
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Establishing and Maintaining Cortical Asymmetry in <i>Drosophila</i> Neural Stem Cells
… on its phosphorylation by the apically localised kinase, aPKC (atypical protein kinase C). This model proposes that aPKC localises to the apical cortex and phosphorylates Miranda, excluding it from the apical domain by phosphorylation of Miranda’s membrane binding motif. However, earlier work …
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