Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Rho kinase inhibitor"”.
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SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION
… activation in the circulation. It was noted that Rho-kinase inhibitor reduced sepsis-induced pulmonary recruitment of neutrophils and tissue injury via regulation of CXC chemokines formation in the lung. Moreover, inhibition of Rho-kinase signaling decreased sepsis-induced T-cell apoptosis as well …
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Structural and functional investigation of the trabecular outflow pathway
… the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and associated morphological changes in normal human eyes and laser-induced ocular hypertensive …
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Investigation of Cell Morphology and Cell-Induced 3-D Matrix Reorganization
… sub-cellular level. To specifically study how Rho and Rac regulate sub-cellular mechanical behavior, cells were plated inside 3-D matrices and incubated with activators and/or inhibitors of Rho and Rac and 3-D optical section images were collected simultaneously. Cell morphology, collagen …
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Mechanisms of neutrophil recruitment in septic lung injury
… pulmonary recruitment of neutrophils along with Rho GTPase subfamily in more than one way for enhancing neutrophil stiffness and migration. Peptides are new evolutionary compound with multifunctional effects, especially during infection and sepsis but potential therapeutic effect of them in …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… and PAR2 agonists stimulated PI hydrolysis and Rho kinase activity and inhibited cAMP formation. PAR1-stimulated PI hydrolysis was abolished in cells expressing Gαq minigene, but was not affected in cells expressing Gαi minigene or in cells treated with pertussis toxin (PTx). PAR2-stimulated PI …
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Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects
… at 20 min was totally abolished by a Rho-kinase inhibitor, indicating that the cytoskeleton of endothelial cells and/or podocytes may be involved. In study IV, high or low doses of ANP induced an increase in glomerular permeability for Ficoll 50-80Å, reaching its maximum at 5 and 15 …
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Die Angiotensin II induzierte Vasokonstriktion isolierter Arterien und deren Beeinflussung durch OxLDL
… fanden sich jedoch viele Hinweise auf eine Rho-Kinase vermittelte Aktivitätsmodulierung der Myosin-Leichtketten-Phosphastase. Die Beteiligung der Rho-Kinase an der Angiotensin II induzierten Vasokonstriktion konnte durch den Einsatz des Rho-Kinase Hemmers Y27632 gezeigt werde. Nach …
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Isolation and characterisation of canine osteosarcoma cells to investigate mechanisms of chemoresistance
… introducing collagenase digest or adding a Rho Kinase Inhibitor to encourage cell attachment. Alizarin Red Staining, alkaline phosphatase (ALP) assay and qPCR on differentiation markers were performed to determine the osteoblastic characteristics of the cells. To determine the …
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Corneal fibrosis therapies and investigations in the canine corna in vitro
… of the drugs, angiotensin-converting enzyme inhibitor (ACE-I) lisinopril and rho-kinase inhibitor (ROCK-I) fasudil, alone and in combination, on the canine cornea using an established in vitro model. Methods: To test the safety and efficacy of lisinopril and fasudil, primary canine corneal …
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Discovery of novel highly selective Rho kinase (ROCK) inhibitory peptides and evaluation of their biological activities
Rho/Rho kinase pathway is a major regulator of actin cytoskeletal dynamics generation of actin-myosin contractility and has been linked to many human diseases including heart failure, hypertension, PAH, atherosclerosis, renal failure, glaucoma, and cancer. This makes ROCK as promising potential …