Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Rho GTPase"”.
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Rho GTPase Signaling Modulates Neurotransmission in Caenorhabditis elegans
Rho family GTPases act as molecular switches in the regulation of diverse cellular functions, including cell division, gene transcription and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and Trio ortholog UNC-73 contains two RhoGEF domains that specifically activate …
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Reconstitution Of Rho Gtpase Interactions At The Membrane
… signal with a robust morphological change. The Rho Family of GTPases play critically important roles in mediating these cellular processes. However, in order for the Rho GTPases to help regulate these processes in a tightly coordinated spatial and temporal manner, they need to be properly …
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… inhibition of prenylation precursors that alter Rho GTPase localization and loading of GTP. We show here that lovastatin decreases neurite initiation and concurrently increases GTP loading of RhoA in the cytosol and decreases GTP loading of Racl associated with the plasma membrane. We also assess …
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Rho GTPase family members in establishment of polarity in C. elegans embryos
… by RNA-mediated interference (RNAi) of two Rho GTPases, CDC-42 and RHO-1. To examine how Rho GTPases are implemented in actin remodeling, it is important to analyze how their activity is controlled and how different activities affect polarity formation. The role of two putative Rho GTPase …
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Characterisation of the expression profile and endothelial function of Rho GTPase RhoJ
Rho GTPases are molecular switches that regulate many aspects of cell physiology. A number of Rho GTPases are essential for the formation of new vessels from pre-existing ones, a process known as angiogenesis. RhoJ/TCL belongs to the Cdc42 subfamily of Rho GTPases. Previous bioinformatic and …
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Signalling and function of the small Rho GTPase RhoJ in endothelial cells
RhoJ is an endothelial expressed Rho GTPase, and its knock-down impairs endothelial cell (EC) migration and tubulogenesis, increases stress fibre (SF) and focal adhesion (FA) numbers. This work aimed to determine the intracellular localisation of RhoJ, identify its binding partners, test how it is …
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Characterisation of the Rho GTPase target Dishevelled Associated Activator of Morphogenesis 1 (DAAM1)
… domains. DAAM1 binds to constitutively active RhoA, Rac1 and Cdc42 but binding did not affect its localisation. The putatively active construct, DAAM1 FH1-FH2-DAD, generated patches in HeLa cells which appeared dark under phase-contrast microscopy. These phase-dark patches co-stained with …
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An Optical Flow Based Methodology for Visualizing Dynamic Sucellular [sic] Organiztion [sic] Demonstrated Through Profilin and Rho GTPase Microdomains
… strategy to map molecular biosensor movies of Rho GTPase signaling into micron scale regions of internally consistent signaling dynamics or "microdomains". Microdomains of GTPases match literature descriptions of signaling organization and in an optogenetic study were found to almost precisely …
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
… cytoskeletal rearrangement largely controlled by Rho GTPase proteins (RhoA, RhoC, Rac-1 and Cdc42) and effector pathways (Rho-kinase; ROCK). Given their pivotal role in directional cell migration, perturbing the function of Rho GTPases is considered a viable anti-metastasis strategy. Disruption of …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
<p>Several studies have identified Rho family GTPases (i.e. Rho, Rac, Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho …
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Veranschaulichung subzellulärer physikalischer Kräfte biochemischen und mechanischen Ursprungs mittels FRET
… Dynamik kontrollieren. Proteine, die der Rho GTPase Familie angehören, spielen hierbei eine wichtige Rolle. Die RhoA GTPase, zum Beispiel, koordiniert gleichzeitig die Entstehung von Faserbündeln und fokalen Adhäsionen (FA). Die Faserbündel zeichnen sich durch ihre kontrahierenden, auf …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
The Rho family of small GTPases has been shown to be required in endothelial cells (ECs) during blood vessel formation. However, the underlying cellular events controlled by different GTPases remain unclear. Here, we assess the cellular mechanisms by which Rho family GTPase proteins and their …
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A Three-Molecule Model of Structural Plasticity: the Role of the Rho family GTPases in Local Biochemical Computation in Dendrites
… and learning. Such efforts have highlighted Rho family GTPases – binary signaling proteins central in controlling the dynamics of the actin cytoskeleton – as attractive targets for understanding how the structural modification of spines might be controlled by synaptic activity. While much has …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
Rho family guanine nucleotide triphosphatases (GTPases) are molecular switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream effectors. Small GTPases are considered active when bound to guanosine …
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HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
… effects are likely due to reduced prenylation of Rho GTPases, evidenced by morpholino-mediated blocking of the prenylation pathway and in vivo assessment of endothelial-specific localization of cdc42, a Rho GTPase family protein. These results are in conformity with recent clinical and …
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Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
… und ist bei Eukaryoten hoch konserviert. Die Rho GTPasen sind in ihrer Funktion als Schlüsselregulatoren zahlreicher zellulärer Prozesse auch wesentlich an der Zellteilung beteiligt. Über die genauen Funktionen der Rho Proteine und deren Regulation in diesem Prozess war zu Beginn meiner Arbeit …
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Bioprobes and Genetics Reveal the Signal Integration That Initiates Dendrites in a Neuron in Vivo
… intrinsic signaling molecules. Monomeric Rho GTPases are capable of mediating diverse transmembrane signal pathways. However, the means to monitor and dissect molecular signaling within a subcellular compartment are limited, and the role of Rho GTPases and their partners remains unresolved …
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Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… cell invasion due to hyperactivation of the Rho GTPases Rac1 and Cdc42. β8 integrin associates with Rho GDP Dissociation Inhibitor 1 (RhoGDI1), an intracellular signaling effector that sequesters Rho GTPases in their inactive GDP-bound states. Silencing RhoGDI1 expression or uncoupling αvβ8 …
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Rab11 Regulates Lumen Formation and Morphogenesis in the Developing Pancreas
… formation. In addition, a literature review of Rho GTPase signaling in the vasculature reinforces many of the fundamental roles of various signaling molecules that also govern pancreas development. These reports link a number of cellular processes in vivo, and presents tantalizing possibilities …
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