Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Rhinosinusitis"”.
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Optimising therapeutic strategies for chronic rhinosinusitis
… optimise current pharmacotherapeutic options in rhinosinusitis. There is often a marked variation in treatment response in those afflicted with chronic rhinosinusitis, both within and between patients, attributable in part to different disease phenotypes/endotypes, poor awareness of treatment …
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Investigation of novel topical therapeutics for chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a common condition that arises from interactions between anatomical factors, perturbations of the local microbial community including the formation of bacterial biofilms, and dysfunction of the host immune responses. First-line treatments are saline nasal irrigation …
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Topical Therapies for the Management of Recalcitrant Chronic Rhinosinusitis
… improve the management of recalcitrant chronic rhinosinusitis (CRS). Chapter one of this thesis reviews the current literature pertaining to CRS including its aetiopathogenesis and the role of the sinonasal microbiome. It also outlines current management and factors leading to poor outcomes …
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Staphylococcus aureus Exoproteins on Nasal Epithelial Barrier in Chronic Rhinosinusitis
Chronic Rhinosinusitis (CRS) is characterised by a plethora of symptoms that patients suffer as a result of chronic inflammation of the sinus mucosa. These are associated with chronic relapsing infections caused by mucosal biofilms that are predominantly due to Staphylococcus aureus. CRS is a …
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On Health-Related Quality of Life and Diagnostic Improvements in Rhinosinusitis
Rhinosinusitis is defined as an inflammatory process involving the mucosa of the nose and one or more of the paranasal sinuses. The aims of the work presented in this thesis were to investigate the degree to which rhinosinusitis affects the health-related quality of life (HRQOL), and to determine …
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The relationship between S. aureus biofilm properties, inflammation, and disease severity in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a serious health problem characterised by chronic inflammation of the sinus mucosa associated with tissue remodelling, dysfunction of the sinuses' natural defence mechanisms, and induction of different inflammatory clusters. Staphylococcus aureus mucosal biofilms are …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… EP4 receptor expression was increased in chronic rhinosinusitis and nasal polyp subjects in contrast to EP1 and EP3, which were down regulated in the polyp group, suggesting a distinctive role of these receptors in the pathophysiology of nasal polyposis. Finally, based on our previous findings and …
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Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… and safe treatment for migraine and allergic rhinosinusitis, but the exact mechanism of action of CO2 in treating these diseases is not well understood. Activation of trigeminal nerves, release of CGRP, and neuron-glia interactions through gap junctions in trigeminal ganglion are implicated in …
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THE DIGITAL NOSE: COMPUTATIONAL FLUID DYNAMICS AS A NEW TOOL FOR THE ASSESSMENT OF PHYSIOLOGICAL, PATHOLOGICAL AND VIRTUAL POST-SURGICAL NASAL AIR FLOW
… In a large study of 4,611 patients with rhinosinusitis, 66 percent of patients exhibited nasal stenosis. In a separate study, it was found in 70% of 755 patients. Several conditions, including rhinosinusitis, nasal septal deviation, concha bullosa (middle turbinate pneumatization), and …
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Comparing the efficiency of beclomethasone, fluticasone and mometasone nasal sprays in a Samter's population
… line of treatment for patients with chronic rhinosinusitis (with or without nasal polyps). The main aim of treatment is to improve nasal symptoms by reducing or eliminating the nasal polyps and preventing polyp recurrence post-operatively. Our aims were to determine if the type of …
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The efficacy of topical agents in the treatment of bacterial biofilms: an in vivo sheep study and an in vitro study.
… biofilms on the mucosa of patients with Chronic Rhinosinusitis (CRS), suggesting their role in the pathogenesis of the condition. This thesis contains two separate studies. The studies investigated novel topical therapies by using previously established in vitro and in vivo biofilm growth and …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… including allergic rhinitis, asthma, and chronic rhinosinusitis. Dendritic cells are known as the type of antigen presenting cells most often associated with allergic inflammation. In this study, we used mouse bone marrow-derived dendritic cells (BMDCs) as a model to study the ability of A. …
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Consequences and Limits of Cell-Cell Communication in Airway Immune Responses
… in Type 2 inflammatory diseases, such as chronic rhinosinusitis. We attribute this overabundance of mast cells to a combination of in situ proliferation and immigration into the tissue. We then fully describe the subtypes of mast cells present, including which intercellular signals each subtype …
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Analysis of the Allergenic Potential of the Ubiquitous Airborne Fungus Alternaria Using Bioinformatics
… mold allergy, allergic rhinitis, chronic rhinosinusitis (CRS) and asthma. Recently it has been proven that an abnormal immunological response to Alternaria most likely contributes to the pathogenesis of upper respiratory airway disorders. In this body of work, we present for the first time …
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Targeting Airway Microbiome Dysbiosis for Preventing Pediatric Subglottic Stenosis
… which has been observed in many diseases such as rhinosinusitis, asthma, as well as subglottic stenosis. Therefore, the goal of this work is to define the role of bacteria in SGS and engineer a preventative treatment by controlling the microbiome. Although conventional antibiotics and steroids are …
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Characterizing the Innate Immune Response of Human Airway Cells to the Unique Fungal Allergen Alt a 1
… diseases such as rhinitis, asthma, and chronic rhinosinusitis are responsible for causing a huge economic burden on patients and society. Patients suffering from asthma often have allergies to pollen, dust mite, and mold. Interestingly, studies have shown that there is a correlation between …
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