Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rhabdovirus"”.
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Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells is Dependent on Microtubules and Actin Filaments
… Vesicular stomatitis virus (VSV) is a prototype Rhabdovirus that has been used to study transport within the cell. We developed a new method of analysis of fluorescence within the cytoplasm called the border-to-border distribution method (BTBDM). The well characterized effect on the distribution …
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Investigation of the Vesicular Stomatitis Virus Matrix Protein: Uncoating and Assembly
… negative-strand RNA virus and is the prototype rhabdovirus to study viral entry, transcription, replication, and assembly. The matrix protein (M) of VSV is a central component of the viral replication cycle. While being the smallest of the viral proteins it is multifunctional and is involved in …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… to killing by the interferon sensitive oncolytic rhabdovirus virus MG1. Although MG1 has affinity for latently/persistently HIV-infected cells, its effectiveness and selectivity can be enhanced. To enhance killing, MG1 was combined with the pro-apoptotic molecules, second mitochondria derived …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… but has no appreciable effect on VSV, a rhabdovirus. We have also shown that TRIM56 forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues 621-750, and augments TLR3-mediated interferon (IFN) induction and establishment of an antiviral state. Yet, …
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Addressing the Downstream Processing Challenges Within Manufacturing of Oncolytic Rhabdoviruses
… the use of monolithic column chromatography for Rhabdovirus purification. Two monolithic anion-exchange columns (2 and 6 µm pore size) and one hydrophobic interaction column (6 µm pore size) were used to examine how column pore size affects virus recovery and contaminant removal. This …
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Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion
… VSV is considered the prototypic <em>Rhabdovirus</em> due to its simple genetic organization, broad host cell tropism, and ability to be easily grown in cell culture. Therefore, VSV has been used as the prototype to study viral entry, transcription, replication, and assembly. Viral …
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The host-pathogen interactions of Chinook Salmon (Oncorhynchus tshawytscha) and the aquatic rhabdoviral pathogen infectious hematopoietic necrosis virus
… necrosis virus (IHNV) is an aquatic rhabdovirus that causes acute disease in Pacific salmon and trout populations in aquaculture facilities and freshwater conservation hatcheries across the northern hemisphere. While disease occurs primarily in juvenile fish, assessment of IHNV …