Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Rhabdomyosarcoma"”.
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A molecular genetic investigation of rhabdomyosarcoma
Alveolar Rhabdomyosarcoma IS characterised by a t(2;13)(q35;qI4) chromosome trartslocation, which leads to the fusion of the P AX3 artd the FKHR genes. The resulting fusion gene encodes a chimeric protein which has aberrant transcriptional activity. The data here describes the molecular definition …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current treatment is associated with debilitating side effects and treatment outcomes for patients with metastatic disease are dismal. Other than a need for alternative and more …
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Role of NPHS Gene in Mammalian Myogenesis and Rhabdomyosarcoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… in a wide range of sarcoma subtypes including rhabdomyosarcomas. This suggests that TBX3 may also contribute to the development and/or progression of sarcomas and potentially may serve as a biomarker for their diagnosis and targete d therapy. This is exciting because sarcomas are diverse and …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) accounts for nearly 50 percent of the soft tissue sarcomas that affect children. There are two major histological variants, alveolar (ARMS) and embryonal (ERMS). Both are defined as sarcomas that show exclusive evidence of muscle differentiation, but differ in their …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… tumor oxygenation in an Rh30 orthotopic rhabdomyosarcoma xenograft model. However, the effects of BEV on the pharmacokinetics of TPT and the antitumor activity of TPT have not been evaluated. This study aimed to investigate the effect of BEV on TPT systemic and tumoral pharmacokinetics …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… MyoD dependent differentiation of myoblasts. In rhabdomyosarcoma (RMS), which is typically referred to as a muscle derived cancer, we found TBX2 was over expressed in both major subtypes of RMS. The deregulated TBX2 repressed the expression of cell cycle regulators, such as p21 and p14/p19, and …
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EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA
… oncogene in number of cancers. We found that in rhabdomyosarcoma (RMS), which is a muscle derived pediatric cancer, EGR1 was expressed in both RMS subtypes, embryonal and alveolar, but with a much higher expression profile in embryonal RMS. This suggests different mechanisms of down regulation of …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
Rhabdomyosarcoma (RMS) is a highly malignant pediatric cancer that is the most common form of soft tissue tumors in children. RMS cells have many features of skeletal muscle cells, yet do not differentiate. Thus, our studies have focused on the molecular defects present in these cells that block …
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Deep Learning-Based Comprehensive Pathology Image Analysis
… applied deep learning on the diseases of rhabdomyosarcoma and oral potentially malignant disorders. Convolutional neural network models were developed, one of which was to predict the risk of oral cancer development from slide images in patient with oral leukoplakia (a type of oral …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… (EWS/pPNET), embryonal and alveolar rhabdomyosarcomas, lymphoblastic lymphoma and Wilms tumor, to assess the potential utility of these markers in the differential diagnosis of these tumors; iii) Ewing Sarcoma derived by culture of human Ewing Sarcoma cell lines, inoculated in a group …
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Electrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells
… based on previous work on myoblasts, cancerous rhabdomyosarcoma cells, and MCF7 breast cancer cells. EPS of MCF7 and MDA-MB-468 breast cancer cells revealed alterations in cellular signaling that suggest cell cycle arrest by autophagy. An Akt inhibitor was used to identify the role of Akt in the …
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Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano
… for the first time MYCN targeted inhibition in Rhabdomyosarcoma (RMS) by the anti-MYCN-PNA in RMS cell lines (four ARMS and four ERMS) and in a xenograft RMS mouse model. Rhabdomyosarcoma is the most common pediatric soft-tissue sarcoma, comprising two main subgroups [Alveolar (ARMS) and …
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Gene Regulatory Networks in Striated Muscle Pathologies
… framework for the function of TWIST2 in rhabdomyosarcoma pathogenesis as well as the mechanisms of heart remodeling and repair following myocardial infarction. In this process, we elucidated critical nodes in complex pathways that can be manipulated to derail the pathological process of …
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Distance to treatment center and other non-medical factors that can influence pediatric cancer survival
… central nervous system tumors, neuroblastoma, rhabdomyosarcoma, or Wilms tumor between the years 2000 and 2018 who were NC residents and treated at UNC Hospital. RESULTS: Distance to the UNC Hospital from a patient’s residence did not have a statistically significant impact on pediatric cancer …
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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation
… </em>was upregulated in RD, Rh41, and Rh30 rhabdomyosarcoma cells and D341 and Daoy medulloblastoma cells as well as NB3 neuroblastoma cells. All three miRNAs were downregulated in Daoy cells. Considering that miR-124 is highly expressed in the brain and is a tumor suppressor, we decided to …
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Effect of breathing hypoxic gas mixtures followed by irradiation on tumour cell survival in experimental mouse tumors
… tumours and 3-methylcholanthrene-induced murine rhabdomyosarcomas was compared with radiation alone. No differences in regrowth delay were observed in the case of the CaNT tumour between the mice that received pre-treatment and radiation and those that received radiation alone. In the …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… analyses on high grade gliomas (HGG) and rhabdomyosarcomas (RMS). Using systems biology approaches, we demonstrated that these newly developed proteomic analysis pipelines are able to (i) define human proteotypes that link oncogenotypes to cancer phenotypes in HGG and to (ii) identify …
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