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Showing 1 to 12 of 12 for “"Rhabdomyolysis"”.
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
In patients with rhabdomyolysis, the overwhelming release of myoglobin into circulation is the primary cause of kidney injury. Myoglobin causes direct kidney injury as well as severe renal vasoconstriction. An increase in renal vascular resistance (RVR) results in renal blood flow (RBF) and …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
<p>Sickle cell syndromes increase the risk of rhabdomyolysis, a potentially life-threatening condition stemming from the destruction of skeletal muscle fibers. Acute kidney injury (AKI), a major complication of rhabdomyolysis, contributes to long-term morbidity through the development of chronic …
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Genetic investigation of recurrent exertional rhabdomyolysis risk and performance in racehorses
Recurrent exertional rhabdomyolysis (RER) is a disease in Thoroughbred and Standardbred racehorses involving repeated episodes of skeletal muscle cell breakdown in response to exercise in otherwise physically fit horses. Based on epidemiological and heritability studies, RER has been hypothesized …
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The Perceived Demands of CrossFit
<p>Rhabdomyolysis is the breakdown of muscle tissue causing myoglobin, creatine kinase, and other intracellular proteins and electrolytes to leak into circulation, disrupting cell homeostasis. Exertional rhabdomyolysis (ER) occurs after extremely rigorous physical training that could include high …
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Statin-induced muscle mitochondrial toxicity
… myopathy ranging from mild muscle pain to fatal rhabdomyolysis. The mechanism of statin-induced myopathy (SIM) is not fully understood and there is currently no convenient and reliable marker of SIM, but mitochondrial dysfunction has been implicated. We sought to investigate the effect of statins …
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Effect of selected drugs on mitochondrial metabolism in an in vitro model of human skeletal muscle
… hypertriglyceridemia, fever, hepatomegaly, rhabdomyolysis, cardiac and/or renal failure. The risk of the syndrome increases with raising dose and duration of propofol administration (˃48 hours). The mechanism of the syndrome is still unknown: pilot studies performed on animal models are …
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Carnosine metabolism and function in the thoroughbred horse
… exercise, however, episodes of equine exertional rhabdomyolysis produced large increases. Carnosine concentrations in tissues, such as the heart, liver and intestine were 10 to 100-fold lower than in skeletal muscle. Carnosine displayed a heterogeneous distribution within skeletal muscle. Its …
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Improving the Use of Mobile Medical Alert Devices in the Elderly
… dehydration, internal bleeding, pressure sores, rhabdomyolysis, or death (Taylor et al., 2016; Lipsitz, Tchall, & Klickstein, 2016). Fall detection devices (FDD) send an alert to summon the assistance of a telephone responder; who notifies family and emergency services to prevent fall from …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between statins and conventional medicines that may inhibit metabolic pathways important to statin clearance. Though drug-drug interactions are well characterised with statins, there …
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Glucose regulation in Thoroughbred weanlings: Regulation by insulin, growth hormone and insulin-like growth factor-I
… with some types of laminitis, exertional rhabdomyolysis and osteochondrosis in horses. This study applied the minimal model of glucose and insulin dynamics to determine the effect of diet on metabolites and hormones that regulate glucose metabolism in young horses. Twelve Thoroughbred …
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Vitamin E Status of Thoroughbred Horses and the Antioxidant Status of Endurance Horses
… muscle cell damage and a new form of exertional rhabdomyolysis (ER) that has been observed in endurance horses, where oxidative fibers are damaged compared to the typical glycolytic fiber damage associated with known forms or ER. An increased understanding of vitamin E utilization in the horse …
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Athlete and Coach Knowledge, Attitudes, and Perceptions of Sickle Cell Trait and National Collegiate Athletic Association Mandated Testing: Recommendations for Intervention
<p>Individuals with Sickle Cell Trait have died suddenly after extreme exertion during military training, athletic practice or games (Kerle & Nishimura, 1996; Harrelson, Fincher & Robinson, 1995; Howe & Bowden, 2007). One of those deaths, Dale Lloyd, a football player at Rice University, prompted a …