Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Reverse Vaccinology"”.
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… of these vaccines. In this study, we used a reverse vaccinology approach to identify outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major …
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Optimization of Burkholderia Glycoconjugate Vaccines: A Reverse Vaccinology Approach
… of these vaccines. In this study, we used a reverse vaccinology approach to identify outer membrane and secreted Burkholderia proteins. These proteins were ranked according to predicted immunogenicity, and top vaccine candidates were selected based on the number and affinity of Major …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… novel antigens identified previously by a reverse vaccinology model. In these studies, we have established an optimal immunization procedure to test the efficacies of several protein-polysaccharide NPs when delivered alone or in a combination containing various proteins in a clinically …
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Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
… vaccine. We have performed an in silico reverse vaccinology screen to scan the B. pseudomallei proteome for such highly conserved surface antigens and identified eight that matched our selection criteria. We recombinantly expressed three of these proteins (OmpA1, OmpA2, Pal) and attached …
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The characterisation of the cell surface of Staphylococcus aureus in the search for new therapeutic targets
… proteins that could not be predicted using reverse vaccinology and other hypothesis-directed approaches commonly used to develop potential vaccine candidates. Ascertaining the repertoire of heparin-binding proteins was considered important as these proteins are bacterial virulence factors …
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Identification of protective rickettsial antigens for vaccine development
… Together, these findings validate a reverse vaccinology approach as a strategy to identify protective rickettsial antigens that induce cellular immunity. In addition, this work demonstrates the feasibility of developing a subunit vaccine that triggers T-cell-mediated cross-protection …
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In Silico Platform for Accelerated Drug and Vaccine Development, Assessment, and Repositioning in Pandemic and Emergency Scenarios [Piattaforma In Silico per lo Sviluppo Accelerato, la Valutazione e il Riposizionamento di Farmaci e Vaccini in Scenari di Pandemia ed Emergenza]
La pandemia di COVID-19 ha evidenziato gravi lacune nella preparazione globale alle pandemie, sottolineando la necessità di strategie rapide e proattive per contrastare le malattie infettive emergenti. Sia il COVID-19 che l'influenza continuano a rappresentare minacce significative, con il …
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Harnessing In Silico platform for Vaccine Discovery, Disease Modeling, and Immunotoxicity Prediction in Pandemic and Emergency Scenarios
Il mondo moderno affronta sfide senza precedenti derivanti da pandemie ed emergenze, richiedendo soluzioni innovative per una gestione efficace. Questa tesi affronta problematiche di salute globale utilizzando strumenti computazionali avanzati per la scoperta di vaccini, la modellazione delle …