Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Reverse Transcriptase Inhibitors"”.
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Towards Rapid Measurement of Non-Nucleoside Reverse Transcriptase Inhibitors in a Portable, Low-Cost Platform
… assay for the measurement of non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on inhibition of DNA synthesis using an inexpensive, portable instrument. This assay is entitled the REverse transcriptase ACTivity (REACT) assay. This work demonstrates proof-of-concept measurement of …
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Synthesis and anti-HIV activity of [d4U]-spacer-[HI-236] bifinctional HIV-1 reverse transcriptase inhibitors
… anucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linkedvia different spacers between C-5 of the NRTI and 0-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner from uridine in 13steps for the butyne target and 19 steps for targets …
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Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children
… associated with Cmin>12.4 mg/L. Non-nucleoside reverse transcriptase inhibitors dosage guidelines for African children should take into consideration the combined effect of SNPs CYP2B6 516G>T and 983T>C, in particular for efavirenz where we observe 10-fold differences in exposures between …
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Mechanism of lipid disorder in HIV infection: apolipoprotein-B kinetics, fat distribution, insulin resistance and adipocytokines in patients taking protease inhibitors or non-nucleoside reverse transcriptase inhibitors
… protease inhibitor (PI, n=15) or non-nucleoside reverse transcriptase inhibitor (NNRTI, n = 25). The HIV positive treatment groups had mild dyslipidaemia. The apo-B fractional clearance rate (FCR) was reduced in the HIV positive groups. Peripheral fat was lower in treated patients and correlated …
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The Prevalence of Antiretroviral-Therapy-related Adverse Reactions, Hospitalisation, and Mortality among People Living with HIV in Africa-A systematic review and Meta-Analysis
… The antiviral implicated, are non-nucleoside reverse transcriptase inhibitors, nucleoside/tide reverse transcriptase inhibitors, and protease inhibitors. The pediatric population was underrepresented as only two studies included pediatric patients. The economic impact of adverse reactions was …
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The pharmacokinetics of lopinavir in HIV-infected adults receiving rifampicin with adjusted doses of lopinavir
… lopinavir/ritonavir (LPV/r) and 2 nucleoside reverse transcriptase inhibitors (NRTls). This review will focus on the data of the drug-drug interactions between the PIs and rifampicin, with an emphasis on LPV/r.
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Cardiometabolic Diseases and HIV Infection: The Impact of Highly Active Antiretroviral Therapy
… therapy (HAART) medications i.e. protease inhibitors (PIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). </p> <p> Methods: The study population included a matched cohort of HIV-infected and non-HIV-infected …
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Cost effectiveness analysis of abacavirlamivudine versus tenofoviremtricitabine combination therapy as part of highly active antiretroviral therapy in treatment naive HIV-infected patients
… of HIV include the use of dual nucleoside reverse transcriptase inhibitors, namely abacavir/lamivudine or tenofovir/emtricitabine. This study is to compare the cost-effectiveness of these two alternatives in the treatment of HIV treatment-naive patients. Methods: A review of the literature …
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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
… as part of HIV therapy, especially nucleoside reverse transcriptase inhibitors (NRTIs). Toxicity from NRTIs manifests through metabolic diseases such as peripheral neuropathy, lipodystrophy, lactic acidosis and hyperlactatemia but show interpatient variability. Studying African populations is …
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Probing the HIV reverse-transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors have prompted the design of double-drugs combining these two entities with the aim of addressing the emergence of resistance as well as searching for synergism between the two drug target sites on HIV reverse …
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Investigating the regulation of APOBEC mutagenesis in cancer
… APOBEC activity is established. Reverse transcriptase inhibitors, which inhibit LINE-1 activity, appear to modulate APOBEC3B expression and associated enzymatic activity. This appears to occur when cells are p53-deficient, but not when p53 is intact. Secondly, the thesis reports …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
Background: Nucleoside reverse transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a …
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Antiretroviral Regimen and Pregnancy Outcomes of Women Living with HIV in a US Cohort
… and on ART is of paramount importance. Integrase inhibitors (INSTIs) are of particular interest as newer data suggests that these can lead to more rapid viral load reduction. This was a retrospective study of women who are pregnant and living with HIV who received prenatal care at the University …
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The inhibition of HIV-1 activity by crude mucus and purified mucin (mucous glycoproteins) from saliva, breast milk and the cervical tract of normal subjects, HIV positive individuals and patients with HIV-AIDS
… therapies which contain both protease and reverse transcriptase inhibitors, HIV remains as a global threat especially to the third world countries. Therefore there is a need for the development of safe compounds to reduce viral loads in infected people and to prevent the transmission of the …
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Drug Resistance Mutations in Naive HIV-1 South African Patients, and Construction of Molecular Clones to Phenotype Putative Resistance Mutations
… of resistance. Thirty protease (PR) and 31 reverse transcriptase (RT) amino acid sequences of HIV primary isolates from drug naNe patients from rural settings in South Africa were examined for resistance mutations. Samples were collected between May and August 2007. Phylogenetic analysis …
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Investigating Mechanisms of Nucleoside Reverse Transcriptase Inhibitor Induced Sensory Neuropathy
… the ART may cause PSN. Although the nucleoside reverse transcriptase inhibitors (NRTIs) used in the ART are thought to contribute to PSN, the mechanisms underlying the PSN induced by NRTIs are unclear. This is partly due to the lack of a good model for mechanistic investigations. In this study, …
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The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients
… cycle. These are nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs/NNRTIs); fusion/entry inhibitors; integrase inhibitors; and protease inhibitors (PIs). In South Africa PIs, specifically lopinavir (LPV) boosted with another PI, ritonavir (RTV) are used in second-line ARV …
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Toxicities associated with antiretroviral treatment of HIV-1
… randomised to either 2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) plus lopinavir/ritonavir (LPV/r) or to raltegravir plus LPV/r. Results: The primary STEAL study was the first randomised controlled trial to support the finding that ABC was associated with adverse …
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Probing the HIV Reverse-Transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors have prompted the design of double-drugs combining these two entities with the aim of addressing the emergence of resistance as well as searching for synergism between the two drug target sites on HIV reverse …
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Distal sensory polyneuropathy in South Africans infected with human immunodeficiency virus : a cross-sectional analysis of a community cohort
… antiretroviral therapy (ART). Dideoxynucleoside reverse transcriptase inhibitors such as stavudine are widely used in resource-poor countries and often associated with neuropathy. The prevalence of DSP in developed countries range from 21% to 63%; little data is available from Africa. We aimed to …
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