Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Reverse Signaling"”.
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Novel Non-Repulsive Outcomes From Ephrin-B Reverse Signaling
… characterization of the physiological roles for reverse signaling through B-subclass ephrins during embryonic development. The stereotypical outcome of Eph-ephrin signaling has long been established as one of cell-cell repulsion, elicited through a localized breakdown of the actin cytoskeleton. …
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Studies of the Mechanisms of Reverse Signaling by CD40L
… traditionally known for its role in forward signaling by engaging CD40 on antigen- presenting cells to promote immune activation. While this pathway is well characterized, there is evidence that CD40L also mediates reverse signaling, acting as a signaling receptor on T cells which enhances T …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… left sides of the body. Although Frazzled/Netrin signaling is required for many axons to cross the midline, netrin and frazzled/DCC mutants still exhibit significant midline crossing, implicating additional pro-crossing mechanisms. The Drosophila embryonic midline provides an ideal model to …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of ephrinB ligand ‘reverse signaling’ is the regulated tyrosine phosphorylation of the cytoplasmic …
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EphB: Ephrin-B Bidirectional Signaling in Retinocollicular Mapping
… potential role for EphB:ephrin-B bidirectional signaling in the development of the visual system. Previous studies of EphB2-/-;EphB3-/- (receptor null mutant) and EphB2lacZ/lacZ;EphB3-/- (EphB2 intracellular signaling deficient mutant) mice established that EphB acting as a ligand mediates RGC …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… evidence of the importance of EphB1 mediated signaling in retinal and callosal axons while attempting to reach their targets. EphB receptor tyrosine kinases direct axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to …
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, have shown that signaling by the PD-1/PD-L1 immune checkpoint may be bidirectional. Hence, we hypothesized that PD-1/PD-L1 signaling promotes malignant …