Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 80 for “"Retroviruses"”.
-
Analysis of factors that affect pseudotyping in retroviruses
Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. Understanding this mechanism would aid development of a safe and efficient …
-
Retroviruses in the common brush-tailed possum (Trichosurus vulpecula)
… details the search for, and characterisation of, retroviruses in a marsupial, the common brush-tailed possum (Trichosurus vulpecula). Initial efforts were directed at detecting exogenous retroviruses in possums, but the majority of the work described in this thesis involved the isolation and …
-
Regulation of exogenous retroviruses and endogenous retroelements by MOV10
… MOV10 potently restricts the replication of retroviruses as well as the propagation of LTR and non-LTR endogenous retroelements. Significantly,RNAi-mediated silencing of endogenous MOV10 enhances the replication of endogenous retroelements, but not exogenous retroviruses demonstrating that …
-
Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
… Those inherited proviruses are termed endogenous retroviruses (ERVs) and have been identified in a variety of animal species representing an extensive viral "fossil" record of past retroviral infections. With the advent of whole genome sequencing projects and high throughput sequencing platforms, …
-
Studies of Entry, Reverse Transcription, and Regulation of Splicing in Retroviruses
<p>The study of retroviruses and their lifecycle has contributed immensely to our knowledge of the world of biology and medicine. The central dogma of the basic flow of genetic information was shattered when the discovery that retroviruses copy their RNA genome into DNA was made. The same enzyme …
-
Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
In this study a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members …
-
Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
… these activities in the context of mammalian retroviruses have been controversial. Using modern, high-throughput small RNA sequencing we provide evidence that the spumaretrovirus bovine foamy virus expresses high levels of viral miRNAs via noncanonical biogenesis mechanisms. In contrast, the …
-
Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
Repetitive sequences, including transposable elements, represent approximately half of the mammalian genome. Epigenetic mechanisms evolved to repress these potentially deleterious mobile elements. However, such elements can be variably silenced between individuals – so called ‘metastable …
-
Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
… still able to inhibit infection in vitro. Murine retroviruses do not exhibit characteristics of hypermutation by mouse APOBEC3 in vivo. However, human APOBEC3G protein expressed in transgenic mice maintains antiviral restriction and actively deaminates viral genomes. The mechanism by which …
-
Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… evolutionarily young murine-specific endogenous retroviruses (ERVs). Some are capable of retrotransposition and many harbour regulatory sequences with the potential to influence host gene expression. Previous work has shown that, at the Agouti Viable Yellow (Avy) locus, an IAP insertion provides …
-
Roles of Cyclic GMP-AMP Synthase in Immune Defense Against Retroviruses and Autoimmunity
… plays essential roles in immune defense against retroviruses as well as in autoimmune diseases caused by self-DNA. HIV infection abrogates adaptive immunity by the depletion of CD4 T cells. However, innate immune defense mechanisms against HIV are largely unknown. We show that pseudotyped HIV can …
-
Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
Human Endogenous Retroviruses (HERVs) are remnants of ancient retroviral infections that have become incorporated into the human genome over the course of our evolution as a species. These fossil viruses have been co-opted by our genome as regulators of cellular gene expression amongst various …
-
The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
Human endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome. While the majority of sequences are defective, containing premature stop mutations and frameshift mutations, a number encode fully functional proteins. HERVs have been proposed as aetiological agents …
-
Investigation of the role of target cell factors in retrovirus transduction
… and specificity of gene transfer of recombinant retroviruses. Successful gene transfer by recombinant retroviruses is a multi-step process and we have focused our efforts on those target cell factors that affect virus entry into the target cell. We have developed an experimental system to study …
-
Biology of the envelope glycoproteins of sheep betaretroviruses
Retroviruses possess several biological features that differentiate them from all other infectious agents. The obligatory integration step of the retrovirus genome into the host genome has allowed these viruses to associate, modulate and alter the biology of the cell with a variety of unique …
-
Reconstitution and Characterization of Human Endogenous Retrovirus-K
<p>Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome …
-
Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… as a mediator of excitotoxicity. Many animal retroviruses of veterinary importance produce neurologic and immunologic syndromes similar to those manifest by HIV-1. The feline retroviruses, feline immunodeficiency virus and feline leukemia virus, are clinically similar to HIV-1 and HTLV-1 …
-
Mechanisms of retroviral replication
… and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new anti-retroviral drugs against such serious pathogens as human immunodeficiency virus types 1 and 2.;This …
-
Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
… does cause dysregulated expression endogenous retroviruses. On the contrary, the interaction between Daxx and H3.3 is not required for embryonic development but is essential for postnatal viability. Transcriptome analysis of embryonic tissues demonstrates that this interaction is important for …
-
A Novel HIV-1 Genomic RNA Packaging Element and its Role in Interplay between RNAPackaging and Gag-Pol Ribosomal Frameshifting
Retroviruses belong to a diverse family of RNA viruses that utilize the eukaryotic translational machinery for viral protein synthesis during infection of its target cells. In the cytoplasm, the unspliced version of retroviral RNA takes one of two pathways: 1) to serve as mRNA template for Gag …
Page 1 of 4