Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Retrovirus"”.
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Reconstitution and Characterization of Human Endogenous Retrovirus-K
<p>Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome …
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Analysis of the role of lipids in retrovirus transduction
… are mammalian virus vectors. Specifically, retroviruses are one of the most common viral vectors used since they are able to permanently integrate their transgene into the host cell genome, providing, in principal, to a long-term cure. The potential applications of gene therapies are vast, …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… cell lines for the presence of human endogenous retrovirus K (HERV-K) Env viral RNA (vRNA), protein, and viral particles. We hypothesize that HERV-K proteins are tumor-associated antigens and as such can be profiled and targeted in patients for diagnostic and therapeutic purposes. To test this …
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Investigation of the role of target cell factors in retrovirus transduction
… and specificity of gene transfer of recombinant retroviruses. Successful gene transfer by recombinant retroviruses is a multi-step process and we have focused our efforts on those target cell factors that affect virus entry into the target cell. We have developed an experimental system to study …
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Targeting An Ancient Retrovirus During Melanoma Using Adoptive T Cells Therapy
… we targeted a TAA derived from human endogenous retroviruses (HERV), whose genome stably integrated into humans millions of years ago. During oncogenesis, biologically active variants of HERV, such as the envelope (env) protein of HERV-K, are expressed on the surface of melanoma, but not normal …
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Analysis of charged polymer effects on recombinant retrovirus-mediated gene transfer success
… the transduction efficiency of recombinant retroviruses in gene therapy experiments. Conversely, chondroitin sulfate proteoglycan is an anionic polymer endogenously present in retrovirus stocks which inhibits transduction efficiency. An experimental study was performed to determine the …
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The Role of Adaptor Protein Grb2 in Ecotropic Retrovirus Entry and Receptor Trafficking
For retroviruses such as HIV-1 and murine leukemia virus (MLV) active receptor recruitment and trafficking occur during viral entry. However, the underlying mechanisms and cellular factors involved in the process are largely uncharacterized. The viral receptor for ecotropic murine leukemia virus …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
Human endogenous retroviruses are the remnants of ancient retroviral infections present within our genome. These molecular fossils show similarities with present day exogenous retroviruses but act as typical Mendelian elements that are passed vertically between generations. Despite being repeatedly …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …
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Transcriptional Heterogeneity in ALS: Patients with Retrovirus-mediated Disease and Potential Cell-type Specific Therapeutic Approaches
… certain loci associated with human endogenous retrovirus K (HERV-K), a type of transposable element (TE), as well as other non-TE features were dysregulated in patient samples compared to controls. In both the CTX and SC, around 20% of ALS patients had higher overall HERV-K expression than …
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Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
Endogenous retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they maintain the ability to interact with their exogenous retroviral (XRV) …
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Genetische und funktionale Vereinfachung eines komplexen Retrovirus am Beispiel des Primaten Foamy Virus Typ 1 (PFV-1)
Foamyviren (Spumaviridae) werden neuerdings von den übrigen Retroviren (Orthoretroviridae) abgegrenzt. Durch verschiedene Besonderheiten in ihrem Replikationszyklus, wie der Möglichkeit zur intrazellulären Retrotransposition oder der reversen Transkription spät im Vermehrungszyklus, nehmen sie eine …
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Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
<p><strong>HUMAN ENDOGENOUS RETROVIRUS K AS A NOVEL TUMOR-ASSOCIATED ANTIGEN FOR DEVELOPMENT OF AN OVARIAN CANCER VACCINE </strong><em></em></p> <p>Publication No.________<br />Kiera Rycaj, B.S.<br />Supervisory Professor: Feng Wang-Johanning, Ph.D., M.D.</p> <p>Ovarian cancer (OC) is the fourth …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… contributory factors. Human endogenous retrovirus K10 (HERV-K10) is one such virus as it retained the capacity to produce viral particles in RA synovium. This study set out to explore how HERV-K10 Gag matrix region could contribute to RA pathogenesis and perpetuation, with particular …
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THE EFFECTS OF RETINOIC ACID ON CELLULAR TRANSFORMATION AND TUMORIGENESIS INVOLVING CELLS WITH KNOWN ONCOGENES (VITAMIN A, RETINOIDS, RETROVIRUS)
Vitamin A is known to have an important role in cellular differentiation and proliferation. In addition to regulating normal cellular processes vitamin A has also been shown to possess potent antineoplastic activity. The work in this dissertation characterizes the role of retinoic acid (RA) in …
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