Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Retinoid X Receptor"”.
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
<p>The ligand activated transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… we show that expression of genes involved in the retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) pathways are decreased with ageing in both myelin-phagocytosing human monocytes and mouse macrophages. Disruption of RXR and PPAR using synthetic antagonists in young …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
… resulting in poor recovery after stroke. Retinoid-X-receptor (RXR) is a pleiotropic transcription factor. Our studies suggest that RXRa enhances MF phagocytic functions, reduces inflammatory responses, and improves post-stroke recovery. To establish phenotypes of aging MF, MG were …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… phase response signaling system and liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) activation. Conclusion: Plasma proteomic profiles are altered in cancer cachexia and disuse-induced atrophy. Modulated protein profiles suggest the …
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Magreceptorok ligandkötési affinitásának vizsgálata FRET szenzorral
Bevezetés: A magreceptorok olyan transzkripciós faktorok, amelyek ligandvezérelt módon képesek transzkripció szabályozására. Inaktív, ligand nélküli állapotukban korepresszor fehérjék gátolják a transzkripció inicializálását. A retinsav receptorok központi szerepet játszanak az endokrin …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… release. Oxysterols are known as nuclear receptor liver X receptor agonists, and these inhibitory effects were observed with synthetic agonists of liver X receptor and retinoid X receptor in a similar manner. In addition, ATP-binding cassette transporter a1 transcription, LXR-induced …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… border. In addition, members of the nuclear receptor superfamily of ligand-activated transcription factors are known to modulate expression of genes involved in cholesterol and bile acid homeostasis, and cholesterol absorption. Therefore, we wanted not only to clarify the essential molecular …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… on cultured neurons. I demonstrated that various retinoid receptor agonists could mimic the chemotropic effects of RA, providing further evidence for a potential role of retinoid X receptor and retinoic acid receptors in growth cone turning. I also examined potential downstream effectors involved …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… its classical signaling pathway, the nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), to mediate gene transcription. Moreover, RA has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… LNCaP cells are weakly metastatic, androgen receptor (AR)-positive and androgen-responsive cells, C4-2 cells are AR-positive and androgen-independent LNCaP variants, and PC-3 cells are highly metastatic AR-negative cells. We identified a negative vitamin D response element (nVDREhPTHrP) …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… on the immunological effects of bexarotene. This retinoid X receptor agonist is currently being tested in a phase II clinical trial for its ability to promote remyelination [“CCMR One” trial]. Here, we focused on the ability of bexarotene to modulate the human Th17/iTreg axis in vitro, owing to …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… oligodendrocytes. In animals, agonism of the retinoid X receptor (RXR)-γ enhances remyelination in this way. Metformin also promotes remyelination, this time by overcoming an age-associated block to the responsiveness of OPCs to pro-differentiation factors. In this PhD I show that bexarotene, …
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The role of retinoic acid in glioma growth control
… that acts as a ligand for a family of nuclear receptors (RARs) to regulate the expression of target genes. The main family of nuclear receptors comprises three genes, RARα, RARβ and RARγ, each coding for multiple isoforms. The selective stimulation of these isoforms with RA has been shown to …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… to which these factors bind. The nuclear receptors, peroxisome proliferator-activated receptor-a (PPARa) and retinoid X receptor-a (RXRa), which are known regulators of cardiac metabolic gene expression also induced transcription from this region. Thus, the 5'-flanking region of the rat …