Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Retinoblastoma protein"”.
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The role of the retinoblastoma protein in mitochondrial apoptosis
The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been most well characterized in its ability to block cell proliferation by …
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Regulation mechanisms of Drosophila retinoblastoma protein stability and repression activity
The retinoblastoma (RB) family proteins are pivotal transcriptional corepressors involved in diverse cellular events. As a potent tumor suppressor, RB plays a variety of important roles including regulating cell cycle, promoting cellular differentiation, inducing cell senescence and balancing …
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Role of retinoblastoma protein in the development of liver cancer
… lack governance. Analysis of the G2/M checkpoint proteins such as Gadd45a, MAD2 and CDC25a all show a dysregulation in their activities. In conclusion Rb loss leads to aberrant regulation of p53 and induces DNA damage, this superimposed on a background of a lack of cell cycle control predisposes …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… cells. It has recently been discovered that the retinoblastoma protein (pRB), typically known for its role in cell cycle regulation, also aids in the maintenance of genome stability. Intriguingly, mutations to the pRB gene, RB1, can arise late in tumorigenesis in cancer cells whose cell cycle …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
The growth suppressive functions of the retinoblastoma protein (pRB), the first identified tumor suppressor, are considerably mediated through the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the …
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Fas-induced apoptosis: dephosphorylation and cleavage of the retinoblastoma protein leads to cell cycle arrest
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… being a by-product of malignant progression. The retinoblastoma protein (pRB) is the prototypic tumor suppressor. Its tumor suppressive properties are linked to its ability to negatively regulate proliferation by inhibiting E2F target gene transcription. Using a gene targeted mouse model defective …
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The retinoblastoma gene family in tumor suppression and development
The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked …
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Regulation of the Arf tumor suppressor by E2F transcription factors
… factors are key downstream targets of the retinoblastoma protein, pRB, and mediate the activation of genes required for cellular proliferation. The Arf tumor suppressor is a key regulator of p53, and causes activation of p53-mediated cell cycle arrest or apoptosis in the presence of …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… factors are critical downstream targets of the retinoblastoma protein (pRB) pathway. A component of the pRB pathway is mutated in most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" …
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Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin In regulation of cell cycle and genome stability
… suggest that at the G1/S-phase transition, when retinoblastoma protein (RB) releases E2 promoter binding factors (E2Fs), g-tubulin associates with and captures E2F to ensure a transient transcription of genes necessary for S-phase entry. In addition, we found that the g-tubulin deubiquitination …
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Molecular analysis of the role of E2F proteins in the pRB pathway
… of the tumor suppressive properties of the retinoblastoma protein. E2F therefore functions in a pathway which is a frequent target in human cancer, and the tumorigenicity of these mutations may be mediated at the transcriptional level by E2F. E2F is also regulated by cell cycle-dependent …
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Antitumor activity of antimalarials in human breast cancer cells
… p21/WAF1, hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1. Quinidine did not show evidence for direct inhibition of histone deacetylase enzymatic activity in vitro. HDAC-1 was undetectable in MCF-7 cells 30 min after addition of quinidine to the …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
… 13 mesangial cells in vitro. Cell proliferation, retinoblastoma protein (Rb) phosphorylation, and NFκB activation were increased in cells transfected with miR-let-7a and stimulated with LPS/IFN-γ. Expression and production of the cell cycle inhibitor E2F5 was decreased in stimulated cells …
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Role of Spz1 in HPV-mediated carcinogenesis
… are not well understood. The HPV oncoprotein E7 plays a central role in viral survival and proliferation in host cells and it is partly responsible for the transformation of cells infected with HPV. Its most studied role is inducing a proliferative state in epithelial cells via …
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Funktion und Regulation von D- und E-Typ-Cyclin-Cdk-Komplexen während der Entwicklung von Drosophila
… von Cyclin E-Cdk(Cyclin-dependent kinase)2-Proteinkomplexen ist essentiell für den Eintritt in die S-Phase. Umgekehrt erfordert der Austritt aus der Zellproliferation zum korrekten Zeitpunkt in der Entwicklung die Inaktivierung von Cyclin E-Cdk2-Komplexen. Es wird allgemein angenommen, dass …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… the cell cycle (Malumbres, Barbacid 2001). The retinoblastoma protein (pRb), and its homologues pRb2/p130 and p107, comprise a gene family which is central in maintaining appropriate cell proliferation and differentiation. The RB proteins bind to and modulate the activity of E2F transcription …
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Characterization of the molecular mechanisms underlying retinoic acid induced growth inhibition in MCF-7 human breast cancer cells.
… correlated with decreased phosphorylation of the retinoblastoma protein (pRb). It also resulted in a down regulation of cyclin dependent kinase 2 (cdk2) and cyclin D1 gene expression and a profound down regulation of cdk2 activity. In contrast, no changes were seen in cdk4 expression or activity. …
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Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
… dephosphorylation of the tumor suppressor Retinoblastoma protein (pRb), which is dependent on activation of Signal Transducers and Activators of Transcription-1 (STAT1) signaling pathways. We observed inhibition of proliferation in wild type NSPCs (WT/NSPCs) as well as a decrease in …
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Funktionelle Analyse der Interaktion und Lokalisation von Replikationsfaktoren und replikationsrelevanten Proteinen in Mauszellen
Zeil dieser Arbeit war die Identifikation von Proteinen, die mit Bestandteilen des für die DNA-Replikation essentiellen präreplikativen Komplexes in der Maus wechselwirken. Hierbei konnten Interkationen des Heterochromatin Proteins 1a mit den Replikationsfaktoren ORC1, ORC2 und CDC6 sowohl in Two …