Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"Retinoblastoma"”.
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Second cancers following treatment for retinoblastoma
… past century have greatly increased survival for retinoblastoma, a rare childhood tumour of the eye, caused by mutations of the RB1 tumour suppressor gene. However, as survival for retinoblastoma has improved, those with the hereditary form of the disease (RB1 germline mutation) have elevated …
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
<p>Retinoblastoma (Rb) is the most common intraocular malignancy in children comprising 4% of all pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed …
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Genomic Characterization of Recurrent Chromosomal Aberrations in Retinoblastoma
Retinoblastoma is the second most common childhood intraocular malignancy and development of the tumour is initiated by bi-allelic loss of the RB1 gene. Bi-allelic RB1 loss may not always directly lead to malignant retinoblastoma. Subsequent mutational events, specifically gain and loss of …
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The role of the retinoblastoma protein in mitochondrial apoptosis
The retinoblastoma protein (pRB) tumor suppressor is deregulated in the vast majority of human tumors. pRB is a well-established transcriptional co-regulator that influences many fundamental cellular processes. It has been most well characterized in its ability to block cell proliferation by …
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The retinoblastoma gene family in tumor suppression and development
The retinoblastoma tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked …
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Targeting CDK to Prevent and Treat Retinoblastoma and other Cancers
… that initiated retinal cells and nascent retinoblastoma tumors are exquisitely sensitive to CDK inhibition in vivo. To uncover what factors predict CDK inhibitor sensitivity, we generated a transcriptional signature, which reports real-time activity of CDK2 (a potent target of most CDK …
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Regulation mechanisms of Drosophila retinoblastoma protein stability and repression activity
The retinoblastoma (RB) family proteins are pivotal transcriptional corepressors involved in diverse cellular events. As a potent tumor suppressor, RB plays a variety of important roles including regulating cell cycle, promoting cellular differentiation, inducing cell senescence and balancing …
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Role of retinoblastoma protein in the development of liver cancer
Hepatocellular carcinoma is the sixth most common cancer worldwide with a diverse aetiology. Dysregulation of the Rb pathway can occur in as high as 92% of liver cancers implicating Rb as an important factor in the progression of the disease. The impact Rb loss has on the development of liver …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… cancers due to the small patient population. Retinoblastoma, a pediatric cancer of the eye, is one example of a pediatric cancer that can benefit from preclinical studies. Over the years various retinoblastoma rodent models have been developed used to test various combination of broad-spectrum …
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Functional investigation of the role of the retinoblastoma protein in genome stability
… cells. It has recently been discovered that the retinoblastoma protein (pRB), typically known for its role in cell cycle regulation, also aids in the maintenance of genome stability. Intriguingly, mutations to the pRB gene, RB1, can arise late in tumorigenesis in cancer cells whose cell cycle …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
The growth suppressive functions of the retinoblastoma protein (pRB), the first identified tumor suppressor, are considerably mediated through the repression of the E2F transcription factors. Functional inactivation of pRB, and subsequent deregulation of E2F activity, is a critical event in the …
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Analysis of the role of the retinoblastoma susceptibility gene in murine development and tumorigenesis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Fas-induced apoptosis: dephosphorylation and cleavage of the retinoblastoma protein leads to cell cycle arrest
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Dissecting the molecular role of distinct binding interfaces on the retinoblastoma tumor suppressor in growth control and tumorigenesis.
The retinoblastoma tumor suppressor protein (pRB) functions to maintain proliferative control and act as a barrier to tumorigenesis. pRB is capable of regulating E2F transcription factors to mediate control of proliferation through transcriptional regulation of S-phase target gene expression. In …
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Exploration of the artificial eye process in children with Retinoblastoma: addressing the psychological impact and potential for technological advancement.
Background: Retinoblastoma (Rb) is the result of genes becoming mutated and can be hereditary (predominately unilateral and unifocal) or non-hereditary (predominately bilateral and multifocal). 70% of unilateral Rb requires enucleation and thus a lifetime supply of artificial eyes. Aim: To explore …
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A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa protein that is implicated in mRNA processing and ubiquitination functions and has been shown to be highly up-regulated in a number of cancers. In humans and mice,RBBP6 interacts with both tumour suppressors p53 and pRb, suggesting that it is …
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Biophysical investigations of the interaction between substrate binding domain of Hsp40 and the RING finger domain of Retinoblastoma Binding Protein 6
… hybrid study, the RING finger domain of the Retinoblastoma binding protein 6 (RBBP6) and the substrate binding domain of heat shock protein 40 (SBDHsp40) suggested a putative interaction between these two proteins. In this study molecular dynamic simulations were used to confirm the …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins (MDR1 and MRP2) over-expressed on retinoblastoma tumor. Ocular cells have …
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Characterizing the contribution of the LXCXE binding cleft to pRB-mediated genome stability and tumor suppression
… being a by-product of malignant progression. The retinoblastoma protein (pRB) is the prototypic tumor suppressor. Its tumor suppressive properties are linked to its ability to negatively regulate proliferation by inhibiting E2F target gene transcription. Using a gene targeted mouse model defective …
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