Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Retinal stem cells"”.
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Proliferation and Potential of Neural and Retinal Stem Cells
The term “stem cell” is often broadly applied to a range of cell types that are relatively undifferentiated and have some capacity for proliferation. In this thesis, I employ a strict definition of stem cells as cells that are capable of both self-renewal and multilineage differentiation. These …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
… retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the presumptive neural retina of the invaginating optic vesicle. The Chx10 gene is …
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
Retinal diseases such as age-related macular degeneration and diabetic retinopathy are the leading cause of blindness worldwide with prevalence and resulting costs projected to increase. There are few available treatments, and their applicability is limited to slowing down the degeneration of the …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… the mammalian retina cannot regenerate. For stem cell therapies to regenerate a functional retina, multiple challenges must be overcome. These include identification of stem cell sources, targeted differentiation into particular retinal neuronal cell types, delivery to the damaged area, …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… evidence suggests that Müller glia are potential stem cells in the adult mammalian retina but have a limited potential to differentiate into retinal ganglion cell (RGC). Understanding the mechanisms regulating expression of RGC specific and axon-guidance genes during development and in retinal …
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
… of nutrients to the foundational layer of cells in the retina, leading to oxidative stress-related apoptosis of first the retinal pigmented epithelium (RPE) and then the photoreceptors. MicroRNAs (miRNAs) are a group of endogenous noncoding RNA molecules that originate from parts of the …