Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Retinal regeneration"”.
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
Retinal diseases such as age-related macular degeneration and diabetic retinopathy are the leading cause of blindness worldwide with prevalence and resulting costs projected to increase. There are few available treatments, and their applicability is limited to slowing down the degeneration of the …
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Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… mammals, zebrafish can regenerate all of their retinal neurons through Müller glial cells, which respond to retinal damage by re-entering the cell cycle to create clusters of progenitor cells. The progenitors continue to proliferate as they migrate to the site of damage, where they ultimately …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… targeted differentiation into particular retinal neuronal cell types, delivery to the damaged area, survival and integration into the remaining retinal tissue, and establishment of appropriate connections between cells. Müller glia have been proposed as potential retinal stem cells, but …
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Characterisation of neural progenitors from the adult retina and ciliary epithelium
… retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina. Chx10 is a paired-like homeobox transcription factor gene expressed in the presumptive neural retina of the invaginating optic vesicle. The Chx10 gene is …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… have a limited potential to differentiate into retinal ganglion cell (RGC). Understanding the mechanisms regulating expression of RGC specific and axon-guidance genes during development and in retinal stem cells is key for successful optic nerve regeneration. I proposed that dedifferentation of …