Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Retinal explants"”.
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An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… endothelial cells (HDMEC) and porcine retinal vasculature is presented with three mechanistic pathways of transcriptional factors regulating the redox (nuclear factor type-2 (Nrf2)), pro-inflammation (Nuclear Factor kappa B; (NFᴋB)), and oxygen signalling (hypoxia inducible factor type …
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Exploring the Role of the Inflammasome Pathway in Diabetic Retinopathy
… further examined using a novel human organotypic retinal culture (HORC) model, where donor retinal explants were cultured in IL-18 without and with high glucose. Results: The NLRP3 inflammasome is activated at the onset of DR, and a significant increase in vitreous IL-18 levels was found in donors …
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Redox biology in retinal degeneration
… legally blind by age 40 due to the loss of retinal photoreceptors. The difficulty in finding a treatment relies on the complexity of its genetics. Although more than 3,000 mutations have been described to cause it, about 40-50% of RP cases still correspond to unknown patterns. In most cases, …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… have a limited potential to differentiate into retinal ganglion cell (RGC). Understanding the mechanisms regulating expression of RGC specific and axon-guidance genes during development and in retinal stem cells is key for successful optic nerve regeneration. I proposed that dedifferentation of …
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The role of Interleukin-33 in retinal degenerative diseases
… and they play an essential role in maintaining retinal homeostasis by supporting neuronal and vascular function. In disease settings, dysregulation of Müller cells leading to their prolonged activation is known to be critical for neurovascular pathology, especially in degenerative conditions …