Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Retinal diseases"”.
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Inherited Retinal Diseases: Towards Clinical Studies and Treatment
Contains fulltext : 250086.pdf (Publisher’s version ) (Open Access)
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Inherited retinal diseases: missing heritability beyond the coding regions
Contains fulltext : 239944.pdf (Publisher’s version ) (Open Access)
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Genetic analysis of inherited retinal diseases in indigenous Southern African populations
Background: Inherited retinal diseases (IRDs) constitute a group of clinically and genetically heterogeneous conditions which cause degeneration of retinal photoreceptor cells and result in visual impairment. Characterisation of the genetic basis of IRD is not only beneficial for the affected …
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Ablation of Retbindin, the Riboflavin Binding Protein, Exacerbates Retinal Degenerative Phenotypes in Mouse Models of Human Retinal Diseases
… the effect of Rtbdn ablation in these retinal degenerative models in order to elucidate the function of this novel protein in retinal health and disease. Although, the ablation of Rtbdn alone (Rtbdn-/-) had no deleterious effects on retinal function up to postnatal day (P) 120, …
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A data acquisition and analysis system for use with multi-electrode arrays in the development of a retinal prosthesis for degenerative retinal diseases
… carried out towards the development of a retinal prosthesis to aid sufferers of degenerative retinal diseases. Millions of people worldwide are blind as a result of diseases such as Retinitis Pigmentosa (RP) and Age Related Macular Degeneration (AMD). These progressively destroy the …
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ΜΕΛΕΤΗ ΤΩΝ ΟΠΤΙΚΩΝ ΠΡΟΚΛΗΤΩΝ ΔΥΝΑΜΙΚΩΝ ΣΤΙΣ ΑΜΦΙΒΛΗΣΤΡΟΕΙΔΟΠΑΘΕΙΕΣ
… OF 44 PATIENTS WITH RETINOPATHIES, REVEALED THAT RETINAL DISEASES WHICH IS THE FIRST NEURON OF THE VISUAL PATHWAYS CAUSE DELAYED CONDUCTION VELOCITY OF THE P100.
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. Jumonji domain containing proteins demethylate tri- and dimethylated histone lysines and regulate chromatin structure. Substrate specificity of Jumonji domain-2 family histone …
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High speed handheld instrument for ophthalmic optical coherence tomography
… of a handheld SS-OCT instrument to screen for retinal diseases. Many retinal diseases are asymptomatic in their early stages and remain undetected until they advance to cause irreversible vision loss. Early detection and treatment of these diseases can prevent permanent damage to the retina. …
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Generation of the electroretinogram M-wave and PII components in the amphibian retina
… in humans and is useful in the diagnosis of retinal pathologies. The investigations reported in this thesis were undertaken with the expectation that a more thorough characterization of ERG generation would enhance the diagnostic utility of the ERG and aid in understanding of the …
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Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography
… standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current …
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Longitudinal Visualization of Neurodegeneration: Digital Biopsy of the Retina
As treatment for most retinal diseases only begins after vision impairing degeneration is detectable, a better understanding of what changes lead to neurodegeneration is required. Due to the isolated physiology of the eye, the classical markers of inflammation are not detectable in-vivo without an …
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Finite element modeling of the human eye
… within the eye that may in turn produce various retinal diseases. The entire eye was modeled using dynamic finite element analysis to incorporate the mechanical effects of all of the substructures on the retina. A set of mechanical properties for each substructure was determined from previously …
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The role of spectrin in Drosophila photoreceptor development.
… eye development and in causing certain retinal diseases.
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Optical frequency domain imaging of human retina and choroid
… choroidal disorders as well as early stages of retinal diseases. The objective of this thesis was to develop a new ophthalmic imaging method, termed optical frequency domain imaging (OFDI), to overcome these limitations. Preliminary imaging of the posterior segment of human eyes in vivo was …
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Development of Multielectrode Electroretinography (meERG) for Human Clinical Use
… for Human Clinical use. Introduction Progressive retinal diseases such as macular degeneration, glaucoma, and retinitis pigmentosa begin with localized dysfunction that spreads, often remaining undetected until advanced stages. Existing clinical electroretinography (ERG) techniques either lack …
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A 3-sided Pyramid Wavefront Sensor Controlled by a Neural Network for Adaptive Optics to reach diffraction-limited Imaging of the Retina
… eye's fundus is the basis for the diagnosis of retinal diseases in ophthalmology. However, the resolution of the images is limited - besides the inevitable diffractive limitation by the finite size of the pupil - by the imperfect optical elements of the eye, causing aberrations. In astronomy, …
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The use of Silent Substitution in measuring isolated cone- and rod- Human ERGs
… that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG recording techniques, interpretation and clinical applications, there is still a limited understanding on how each photoreceptor class contribute to the ERG …
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The use of silent substitution in measuring isolated cone- & rod- human electroretinograms. An electrophysiological study of human rod- and cone- photoreceptor activity derived using silent substitution paradigm
… that is conventionally used in assessment of retinal function in health and disease. Although there is ongoing research in developing ERG- recording techniques, interpretation and clinical applications, there is still a limited understanding on how each photoreceptor class contribute to the …
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High A-scan rate optical coherence tomography angiography for blood flow speed quantification in the retina
… non-invasive and depth-resolved imaging of the retinal vasculature. While OCTA is widely used to study retinal disease, it traditionally provides limited information about blood flow speed. This thesis introduces a second-generation variable interscan time analysis (VISTA) OCTA, designed to …
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