Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Retinal degeneration"”.
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Redox biology in retinal degeneration
… legally blind by age 40 due to the loss of retinal photoreceptors. The difficulty in finding a treatment relies on the complexity of its genetics. Although more than 3,000 mutations have been described to cause it, about 40-50% of RP cases still correspond to unknown patterns. In most cases, …
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Mechanisms of microglia induced retinal degeneration
Retinal neurodegenerative diseases including age-related macular degeneration(AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR) and glaucoma arecharacterized by irreversible vision loss and currently have very limited therapies.Evidence has suggested the immune profile and inflammatory …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
"Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among adults, age 60 and older, in developed countries. While oxidative stress is implicated in the pathogenesis of AMD, clinical studies have shown that dietary antioxidants can delay progression of AMD. …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. By 21 days after birth virtually all rod photoreceptors in the retina have died, and subsequent cone degeneration …
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Molecular and Ocular Characterization of Novel Fibulin-3 Variants Involved in Retinal Degeneration
Pages xi-xxiv are misnumbered as pages x-xxiii.
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Splicing The Clock Is Timeless: From Fruit Fly Behavior To Mammalian Retinal Degeneration
… whether clock disruption could contribute to retinal degeneration.
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Microglial activation in the harlequin mouse retina as a mechanism for early retinal degeneration
The prevalence of aging-related retinal degenerative disorders is rising amongst human populations and the origins and early mechanisms of retinal disease remain poorly understood. A model of premature aging, the harlequin mouse, was used to test the hypothesis that parainflammation, a response to …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
Worldwide, age-related macular degeneration (AMD) is one of the most frequently ocurring diseases associated with blindness. Previous studies have provided evidence for the role of inflammation and oxidative stress in AMD progression. It has also been found that connexin hemichannels play a role in …
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Role of oxidative stress in photoreceptor degeneration
… which is a diverse group of inherited human retinal dystrophies associated with progressive degeneration of photoreceptor cells. Mutations in numerous genes have been implicated in RP, which have distinct pathophysiological mechanisms and lead to retinal degeneration at different rates. The …
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DNA methylation landscape in retinal degenerative diseases: implications for Public Health at the crossroad between genes and diet
… methylation process in the pathophysiology of retinal degenerative diseases, exploiting a multiple integrated approach. Findings from in vitro studies uncovered how pathological features of retinal degeneration - including oxidative stress, inflammation and hyperglycaemia - modulate DNMTs and …
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Elucidating the Genetic Basis of Canine Progressive Retinal Atrophies in Several Breeds of Dog
Canine progressive retinal atrophies (PRA) are a group of hereditary diseases characterised by rod and cone photoreceptor cell death in the retina. This study sought to elucidate novel PRA-associated variants of distinct forms of PRA in three breeds of dog: the Lhasa Apso (LA), Giant Schnauzer (GS) …
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Controlled ablation of rod photoreceptors in transgenic Xenopus laevis
Retinal degeneration is the progressive loss of neurons lining the posterior surface of the eye. Loss of a certain group of neurons called rod photoreceptors can occur as the result of genetic mutation. In humans, and in mammalian models of retinal degeneration, the death of these cells is …
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Retinal function in deaf-blind syndromes
A variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the …
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Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
… Gcn5 expression accelerates both cerebellar and retinal degeneration in a mouse model of SCA7. Deletion of Gcn5 in Purkinje cells in mice expressing wild type Atxn7, however, causes only mild ataxia and does not lead to the early lethality observed in SCA7 mice. Reduced Gcn5 expression strongly …
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Steroid induced neuroprotection of damaged photoreceptor cells
… making it the most prevalent inherited retinal disease worldwide, yet currently there is no cure. In 2011, our group released a paper detailing the protective effects of the synthetic progestin ‘Norgestrel’. A common component of the female oral contraceptive pill, Norgestrel was shown …
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Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
… analyzed considering its involvement in neurodegeneration. Specifically, we examined its role in an experimental setting of retinal ganglion cells (RGC) degeneration, a well-established model of several eye disorders including prematurity-induced retinal degeneration, glaucoma, and age-related …
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A system for efficient neural stimulation with energy recovery
… the MIT and Massachusetts Eye and Ear Infirmary Retinal Implant Project to develop a prosthesis for restoring some useful vision to patients blinded by retinal degeneration. Such a prosthesis would receive image data from an external camera and electrically stimulate surviving ganglion nerve …
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Image-Based Biomarkers in Retinal Disease: Applications in Macular Degeneration
… provides the basis for the diagnosis of most retinal diseases so effective characterization of endogenous molecular and morphological biomarkers may provide greater insight into the underlying biological processes responsible for tissue damage and visual dysfunction. Moreover, the non-invasive …
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