Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Retinal Imaging"”.
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Integrated computational system for portable retinal imaging
… designed to image the surface of the retina. The retinal tissue, as well as having various diseases of its own, is unique being the only internal tissue in the human body that can be imaged non-invasively. This allows for diagnosis of diseases that are not limited to eye conditions, such as …
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Second Harmonic Generation – A Novel Approach in Retinal Imaging
… Second Harmonic Generation (SHG) for label-free imaging of microtubules (MTs) in the retinal nerve fiber layer (RNFL). MTs are an important part of axonal cytoskeleton, providing structural support and serving as a railroad in intracellular transport. We demonstrate the application of SHG …
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Development of Multi-modal and Super-resolved Retinal Imaging Systems
<p>Advancements in retinal imaging technologies have drastically improved the quality of eye care in the past couple decades. Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) are two examples of critical imaging modalities for the diagnosis of retinal pathologies. However …
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Structure-function relationships in Age-related macular degeneration in an era of multi-modal retinal imaging
… impairment in the western world. Multimodal imaging has contributed a lot into disease detection, diagnosis and management. The availability of multimodal imaging is an unprecedented advantageous opportunity into relating structure with function in the presence of disease. <br/><br/>The …
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Spectral/ Fourier domain Doppler Optical Coherence Tomography in the rodent retina
Optical Coherence Tomography (OCT) is an emerging imaging technique based on low-coherence interferometry for noninvasive, high- resolution, cross-sectional imaging in a variety of biomedical fields. In ophthalmology, OCT has rapidly become a standard clinical diagnostic tool for retinal diseases, …
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High-speed Fourier domain Optical Coherence Tomography for structural and functional imaging of the retina
… (OCT) is an emerging optical biomedical imaging technology that enables cross-sectional imaging of scattering tissue with high sensitivity and micron-scale resolution. In conventional OCT, the reference arm path length in a Michelson interferometer is scanned in time to generate a profile …
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Microglial activation in the harlequin mouse retina as a mechanism for early retinal degeneration
The prevalence of aging-related retinal degenerative disorders is rising amongst human populations and the origins and early mechanisms of retinal disease remain poorly understood. A model of premature aging, the harlequin mouse, was used to test the hypothesis that parainflammation, a response to …
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High A-scan rate optical coherence tomography angiography for blood flow speed quantification in the retina
… (OCTA) offers non-invasive and depth-resolved imaging of the retinal vasculature. While OCTA is widely used to study retinal disease, it traditionally provides limited information about blood flow speed. This thesis introduces a second-generation variable interscan time analysis (VISTA) OCTA, …
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Image-Based Biomarkers in Retinal Disease: Applications in Macular Degeneration
… a combination of non-invasive high resolution imaging techniques. High resolution imaging and sensing provides the basis for the diagnosis of most retinal diseases so effective characterization of endogenous molecular and morphological biomarkers may provide greater insight into the underlying …
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Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography
… tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid …
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Functional Spectral Domain Optical Coherence Tomography Imaging
… (SDOCT) is a high-speed, high resolution imaging modality capable of structural and functional resolution of tissue microstructure. SDOCT fills a niche between histology and ultrasound imaging, providing non-contact, non-invasive backscattering amplitude and phase from a sample. Due to the …
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Morphometric measurements of the retinal vasculature in ultra-wide scanning laser ophthalmoscopy as biomarkers for cardiovascular disease
Retinal imaging enables the visualization of a portion of the human microvasculature in-vivo and non-invasively. The scanning laser ophthalmoscope (SLO), provides images characterized by an ultra-wide field of view (UWFoV) covering approximately 180-200º in a single scan, minimizing the discomfort …
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Knowledge Mining In The Clinical Assessment Of Glaucoma
… changes in the optic nerve head (ONH) and retinal nerve fibre layer (RNFL) that can be evaluated by various retinal-imaging techniques such as scanning laser polarimetry and optical coherence tomography (OCT). The structural damage can lead to functional damage in the visual field (VF), …
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Artifact removal in digital retinal images
… impairment that could be addressed or prevented. Retinal imaging is a key step in the diagnosis and follow-up of major causes of visual impairment. As much as 20% of retinal images collected in the population are affected by artifacts, that render them ungradable both by expert graders and by the …
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The retinal microvasculature as an early indicator of chronic disease risk in older populations
… been suggested that the measurement of retinal blood vessel parameters could provide an increased understanding of chronic systemic diseases with a vascular component. This easy, non-invasive imaging modality provides an indication of microvascular health that may reflect ongoing changes …
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Ultrahigh speed optical coherence tomography for ophthalmic imaging applications
… non-contact, non-invasive, micron-scale optical imaging technology that has become a standard clinical tool in ophthalmology. Fourier domain OCT detection methods have enabled higher sensitivity and imaging speeds compared to previous generation timedomain OCT. Spectral / Fourier domain OCT …
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Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
… tomography (OCT) is a non-contact volumetric imaging modality that is well suited to image the anterior and posterior human eye in vivo. The success of OCT in clinical ophthalmology motivated the development of intraoperative OCT to overcome the limitations of the operating microscope for …
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Adaptive optics aberrometer and wavefront corrector using a twisted-nematic liquid-crystal on silicon chip
… for in order to provide diffraction-limited imaging. This thesis investigates the aspects of establishing an adaptive optics system for the correction of ocular wavefront errors using a twistednematic liquid-crystal on silicon (TN-LCoS) chip as the wavefront corrector in conjunction with a …
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Enhanced Vasculature Imaging of the Retina Using Optical Coherence Tomography
… coherence tomography (OCT) is a non-invasive imaging modality that uses low coherence interferometry to generate three-dimensional datasets of a sample's structure. OCT has found tremendous clinical applications in imaging the retina and has demonstrated great utility in the diagnosis of …
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Development of Multielectrode Electroretinography (meERG) for Human Clinical Use
… for Human Clinical use. Introduction Progressive retinal diseases such as macular degeneration, glaucoma, and retinitis pigmentosa begin with localized dysfunction that spreads, often remaining undetected until advanced stages. Existing clinical electroretinography (ERG) techniques either lack …
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