Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Respiratory virus"”.
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
… antibodies from commercial sources to detect respiratory virus antigens in clinical specimens and to define the epidemiology of respiratory viruses in Bismarck, North Dakota.</p> <p>Throat swab, nasopharyngeal swabs and nasopharyngeal washes were excellent specimens for studying viral …
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Influenza C : a pilot study investigating the prevalence in Lancaster of a neglected respiratory virus
Influenza C is a virus found throughout the world that can cause respiratory illness, ranging from mild colds to pneumonias. Typically affecting younger children, it is a virus which can cause considerable illness and complications, and yet research into the virus is lacking. This study aimed to …
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The effects of maternal and postnatal infections with porcine reproductive and respiratory virus on muscle growth and development in piglets
… with control pigs. Porcine reproductive and respiratory virus infection decreased muscle weights and cell size through a decrease in myogenic growth factor expression. However, differences between muscles suggest muscles may respond differently to PRRSV infection depending on their fiber type …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… Moreover, in addition to causing acute disease, respiratory virus infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… Moreover, in addition to causing acute disease, respiratory virus infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists …
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Host-Virus Interactions in Asthma and COPD
… impact on exacerbation frequency and severity. Respiratory viral infections are hypothesized to be important triggers of exacerbations. It has been shown that 41-95% of asthma exacerbations and 22-57% of COPD exacerbations are associated with a respiratory virus in-fection, the most common agent …
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Investigating the role of Sialoadhesin in Influenza A virus infection
… cells can mediate the uptake of a sialylated respiratory virus to initiate infection, it remains unclear if Sn will be able to recognize a pathogen devoid of terminal Sia, but triggers its upregulation through a type I IFN response. The aim of this thesis is therefore, to address Sn’s …
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The flattening of the COVID-19 pandemic curve and the legal paradox of socio-economic rights in South Africa
… have been brought on by COVID-19, an infectious respiratory virus that causes symptoms similar to those of pneumonia. This study seeks to interrogate the implications of the legal approaches taken to address COVID-19 pandemic issues on the socio-economic rights in South Africa. To better …
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Developing Interpretable Data Mining Frameworks for Addressing Biomedical Challenges in Genomics and Imaging
… have witnessed multiple widespread outbreaks of respiratory viruses including Influenza A and SARS-CoV-2, alongside a marked increase in chronic conditions such as diabetic retinopathy (DR). These diseases pose serious health threats – respiratory infections can progress to fatal multi-organ …
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Neuroinflammatory consequences of rhinovirus infection in the human airway
Rhinovirus (RV) is the leading cause of exacerbations of airway disease, during which the airways become hypersensitive and manifests clinically with troublesome bouts of cough. The mechanism responsible for respiratory virus induced cough in humans is unknown. This research aimed to determine …
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Effects of emphysema and chronic hypoxemia on skeletal muscle oxygen supply and demand
… and fatigue index. Due to a presumed rat respiratory virus, which likely resulted in the control group being nearly as hypoxemic as the elastase-induced emphysema group, this study was not able to definitively test the hypothesis that chronic hypoxemia leads to both a diminished supply and …
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Applying at scale genomic and phenotypic approaches to study pathogens linked to nosocomial transmission and disease
… resistance, to seasonal epidemics of respiratory viruses and global pandemics, all of which cause high levels of morbidity, mortality and burden on healthcare systems. In this thesis I have investigated three pathogens that are archetypes of these threats: the Gram-negative bacterium …
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Mitigation of Bovine Respiratory Disease Complex: Interactions of Physiology, Immunology, Nutrition and Management
… determine the effects of on-arrival vs. delayed respiratory vaccination and exposure to persistently infected bovine viral diarrhea virus challenge on health, gain performance, and physiological and immunological measurements in newly received stocker cattle. Two experiments evaluated timing (d 0 …
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Studies on severe acute respiratory syndrome coronavirus type -2 in Northern South Africa
… family into the human population, causing severe respiratory disease with increased morbidity rates. A dearth of information exists on human coronavirus (HCoV) molecular epidemiology, and circulation in different populations in Africa. As the COVID-19 pandemic progressed across the globe, …
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A Molecular Epidemiological Study of Human Parainfluenza 4 in the Western Cape, South Africa
… 4 (HPIV 4) is a recognised cause of acute respiratory infection (ARI). However, there is no published data on the epidemiology of this virus in South Africa. This thesis describes the molecular epidemiology of HPIV 4 over a 4-year period (2014-2017). Respiratory samples from infants, …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… including lung inflammatory diseases and respiratory virus infections. NGF can be produced and act upon both structural and non-structural cells of the airways, and overexpression of NGF causes morphological and physiological changes in the airways, such as an increased innervation …
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The effects of dietary soy isoflavone supplementation on carcass cutability and meat quality of pigs infected with porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory virus is (PRRSV) is endemic in the U.S. swine industry. Understanding the viral effects on pig growth and meat quality is essential to characterizing the true impact of infection. Interventions to mitigate the detrimental effects of infection are necessary to …