Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Respiratory Viruses"”.
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Sterility and immunogenicity of gamma-irradiated respiratory viruses
… sterilising doses that is highly applicable to viruses and bacteria. Our research group has developed a whole-inactivated influenza A virus (IAV) vaccine using γ-radiation (γ-Flu). IAV presents a constant pandemic threat due to the mutagenic nature of the virus and the inadequacy of current …
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Toward a Mechanistic Understanding of Inactivation of Respiratory Viruses in the Environment
Airborne transmission of most respiratory viruses was not widely acknowledged until the COVID-19 pandemic. For viruses to transmit between infected and healthy individuals, they must remain stable (i.e., "survive") in aerosols and droplets. Their stability is influenced by many factors including …
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Quantifying the effect of climate on respiratory viruses: From seasonality to interannual variability
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Pathogenesis of the clinical synergy between respiratory viruses and bacterial endotoxin in the lungs of pigs
Pathogenesis of the clinical synergy between respiratory viruses and bacterial endotoxin in the lungs of pigs
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INVESTIGATION OF NEW THERAPEUTIC TARGETS OF RESPIRATORY VIRUSES: A NOVEL METHOD EXPLOITING UV RADIATION ¿ PROOF OF CONCEPT BASED ON SARS-COV-2 ¿
… those with high mutation rates like RNA respiratory viruses. Understanding the virus's seasonal dynamics and identifying new potential therapeutic targets are key factors in controlling outbreaks. In this context, our study has investigated the inhibitory effects of ultraviolet (UV) …
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Developing Interpretable Data Mining Frameworks for Addressing Biomedical Challenges in Genomics and Imaging
… have witnessed multiple widespread outbreaks of respiratory viruses including Influenza A and SARS-CoV-2, alongside a marked increase in chronic conditions such as diabetic retinopathy (DR). These diseases pose serious health threats – respiratory infections can progress to fatal multi-organ …
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
… antibodies from commercial sources to detect respiratory virus antigens in clinical specimens and to define the epidemiology of respiratory viruses in Bismarck, North Dakota.</p> <p>Throat swab, nasopharyngeal swabs and nasopharyngeal washes were excellent specimens for studying viral …
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Influenza Dynamics from Pre-pandemic to Post-pandemic Periods: Epidemiology and Genetic Characteristics
… significantly impacted the circulation of many respiratory viruses, including influenza viruses. While previous studies have examined broader trends of various respiratory viruses throughout the COVID-19 pandemic, research on influenza epidemiology and evolution in Australia spanning the pre- to …
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Cloning and expression of the M-gene from the human coronavirus NL-63 in different expression systems
Respiratory tract infections are one of the leading causes of morbidity and mortality across the world. This is especially true for infants, young children, the elderly and the immunocompromised. The strain placed on economies and health care systems of all countries by these diseases are …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… the primary site of infection for many respiratory viruses, including influenza A virus (IAV). To safeguard this tissue and maintain the functionality of the lung, humans possess a two-layer, extracellular, mucus barrier composed predominantly of individual proteins termed mucins. …
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Performance and energy efficiency of low irradiance antimicrobial violet-blue light for environmental decontamination applications
… of SARS-CoV-2, and potentially other respiratory viruses, within occupied environments. This research significantly advances fundamental knowledge of the germicidal efficiency of low irradiance 405-nm light, furthering clinical delivery of this novel environmental decontamination …
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The regulation and function of viperin during rhinovirus infection
… role in orchestrating innate immune responses to respiratory viruses, including rhinovirus. Interfacing with inhaled material in the airway lumen, the airway epithelium experiences continuous onslaught from respiratory pathogens. To combat viral infection, cells of the airway epithelium express a …
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Factors affecting diagnostic and prognostic performance of a transcriptomic signature of risk of tuberculosis in HIV-uninfected South African adults
… in which a cross-sectional study of upper respiratory organisms was nested. Effects on RISK11 were quantified using multivariable generalised regression. Discriminatory performance of RISK11, and RISK11/QuantiFERON combinations, were quantified by area under the curve and/or sensitivity and …
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Intersecting Threats: Exploring Obesity's Impact on Viral Pathogenesis and Transmission
… been shown to aggravate disease outcomes of respiratory viruses like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mosquito-borne viruses like West Nile Virus (WNV), chikungunya virus (CHIKV) and Mayaro virus (MAYV) and reduce the vaccine efficacy for influenza and …
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Maturation of pluripotent stem cell-derived alveolar type II cells at air-liquid interface and response to environmental stimuli
… exposed to inhaled environmental stimuli such as respiratory viruses and cigarette smoke. Primary human AT2s can be cultured in vitro in three-dimensional organoids known as alveolospheres, but are difficult to culture in the physiologically relevant air-liquid interface (ALI) format due to their …
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A nutriceutical approach to inhibiting H1N1 influenza infection
The disease burden caused by respiratory infections in the human infant is greater than any other disease. Human influenza and respiratory syncytial viruses are two major causes of respiratory infections in infant and young children and often augment the development of subsequent bacterial …
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Applying at scale genomic and phenotypic approaches to study pathogens linked to nosocomial transmission and disease
… resistance, to seasonal epidemics of respiratory viruses and global pandemics, all of which cause high levels of morbidity, mortality and burden on healthcare systems. In this thesis I have investigated three pathogens that are archetypes of these threats: the Gram-negative bacterium …
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EPIDEMIOLOGICAL AND FUNCTIONAL APPROACHES TO EVALUATE THE EFFECTS OF PARTICULATE MATTER EXPOSURE IN INFANTS WITH VIRAL BRONCHIOLITIS
… has been linked to the exacerbation of acute respiratory diseases, especially in the most susceptible population’s subgroups, such as infants and chil\dren. Acute bronchiolitis, a common clinical condition characterized by inflammation and obstruction of bronchioles, is generally caused by a …
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Mechanisms of virus infection of human airway epithelium cultured at an air-liquid interface (HAE-ALI)
… (HAE) cultures are instrumental for studying respiratory tract diseases and gene delivery of airways. Primary epithelial cells isolated from tracheobronchial airways, grown in transwell at an air-liquid interface (ALI), undergo media-induced mucociliary differentiation. This process reproduces …
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