Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Respiratory Syncytial Virus (RSV)"”.
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Developing a Plant-Based Vaccine Against the Respiratory Syncytial Virus (Rsv)
The progression towards fruit-ripening is a highly coordinated process. Fruit softening is the result of polygalacturonase (PG) enzyme activation. The fruit-ripening promoter and the terminator regions from PG were sequenced. BLASTn analysis reveals sequence homology to genes involved in ethylene …
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Antikörper-Entwicklung nach Respiratory Syncytial Virus (RSV)-Infektion bei Frühgeborenen und Säuglingen
Das RS-Virus ist die Hauptursache für Erkrankungen des unteren Respirationstraktes bei Säuglingen und Kleinkindern. In einer prospektiv durchgeführten Studie im Winterhalbjahr 1994/95 wurden 29 nosokomial (Studie 1) und 35 extern (Studie 2) mit dem RS-Virus infizierte Kinder untersucht. Das …
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Long-term effect of respiratory syncytial virus (RSV) infection on children: a prospective longitudinal birth cohort study in Bangladesh
BACKGROUND: Respiratory Syncytial Virus (RSV) is a leading cause of illness among neonates and young infants. In 2019, an estimated 33 million [95% CI: 21·6-50·3) RSV-associated acute lower respiratory infected (RSV-ALRI) episodes occurred worldwide in children younger than five years, and 101,400 …
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Mathematical model for tripledemic disease (COVID-19, RSV, and Influenza)
… circulation of COVID-19, Influenza (Flu), and Respiratory Syncytial Virus (RSV), collectively termed the ”Tripledemic,” poses substantial public health challenges due to their overlapping transmission patterns and compounded healthcare demands. The discovery of COVID-19 vaccines such as Moderna …
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RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
… countries carry the largest burden of Respiratory syncytial virus (RSV) disease, with most deaths occurring in these settings. This study aimed to investigate the burden of RSV disease in South African children hospitalised with lower respiratory tract infection (LRTI), with specific …
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections (LRTIs) in young children and of hospitalization for any reason in the first year of life. Beside supportive management, specific treatments for severe RSV LRTIs are not yet available and the development of …
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A guinea pig model of human respiratory syncytial virus lung infection
Children who have an episode of acute respiratory syncytial virus (RSV) bronchiolitis are at increased risk for developing asthma, a disorder characterized by reversible airway obstruction, airway hyperresponsiveness and airway inflammation. Because latent or persistent pulmonary viral infections …
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Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
As respiratory syncytial virus (RSV) is a respiratory pathogen that causes significant morbidity and mortality in infants, there has always been great interest in the development of a vaccine. In the 1960s, children were immunized with formalin-inactivated (FI)-RSV vaccines. Not only did these …
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Novel Lipid Polymer Design for Nucleic Acids Delivery
… (TNBC) cells (MDA-MB-231) and siRNA against Respiratory Syncytial Virus (RSV) viral proteins in human lung cancer A549 cells. We hypothesize that incorporating hydrophobically modified polyethyleneimines (PEIs) into optimized LNP formulations will enhance the delivery of nucleic acids. We …
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The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
Respiratory Syncytial Virus (RSV) is the leading cause of epidemic respiratory tract illness in children worldwide. Although the mechanisms of RSV-induced airway disease are unknown, experimental evidence suggests that early local inflammatory processes serve as major initiating events in the …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
Background: Lower respiratory tract infections in childhood, including viruses such as respiratory syncytial virus (RSV), are strongly linked to development of allergic asthma. The aim of this project was to develop a mouse model of the induction phase of childhood asthma, to facilitate …
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Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal Pneumonia Virus of Mice.
Respiratory syncytial virus (RSV) is the major causative agent of acute lower respiratory tract infections in infants and young children. Unfortunately, there are no licensed RSV vaccines available, and the few treatment options for high-risk individuals are either extremely costly or cause severe …
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
… a significant delay in growth when infected with Respiratory Syncytial Virus (RSV). On the other hand, pups born to mothers treated with Polymyxin B during gestation or gestation plus nursing were susceptible to Nippostrongylus brasiliensis (Nb) infection. In the second study, we infected female …
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Host cell signaling in response to RSV infection
RSV infection is the most important cause of hospitalization of infants, and is also the major cause for admissions in adults with chronic cardiac disease and pulmonary diseases. So far, there is no effective treatment or vaccine against RSV infection. Intensive studies have been performed to …
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… Several cohort studies have linked severe respiratory syncytial virus (RSV) bronchiolitis in infancy with a higher risk of developing recurrent wheeze or childhood asthma, yet the pathomechanism behind this phenomenon remains undetermined. Here I hypothesise that RSV infection can …
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Identifizierung und Charakterisierung von Interaktionen der Nichtstrukturproteine NS1 und NS2 des Respiratorischen Synzytialvirus mit Proteinen der Wirtszelle
… only members of the subfamily Pneumovirinae like Respiratory Syncytial Virus (RSV) encode two nonstructural proteins, NS1 and NS2. These two proteins cooperatively mediate type I interferon resistance and prevent induction of interferon in infected cells. Interactions of NS1 and NS2 proteins in …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… samples tested using PCR yielded human cytomegalovirus 24.3% (44/181), K. pneumoniae 17.7% (32/181), H. influenzae non-type b 16.0% (29/181), S. pneumoniae and S. aureus 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii …
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Identification of potential pathogens of pneumonia in sputum samples from adult patients at the University Teaching Hospital in Lusaka
… samples tested using PCR yielded human cytomegalovirus 24.3% (44/181), K. pneumoniae 17.7% (32/181), H. influenzae non-type b 16.0% (29/181), S. pneumoniae and S. aureus 9.4% (17/181) each. Other agents, which included Rhinovirus (5.5%, 10/181), M. catarrhalis (4.4%, 8/181), Pneumocystis jirovecii …
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EPIDEMIOLOGICAL AND FUNCTIONAL APPROACHES TO EVALUATE THE EFFECTS OF PARTICULATE MATTER EXPOSURE IN INFANTS WITH VIRAL BRONCHIOLITIS
… has been linked to the exacerbation of acute respiratory diseases, especially in the most susceptible population’s subgroups, such as infants and chil\dren. Acute bronchiolitis, a common clinical condition characterized by inflammation and obstruction of bronchioles, is generally caused by a …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
<p>Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis in children. We have shown that neonatal mice respond to primary RSV infection with T helper type 2 (Th2) biased immune responses, which are enhanced following reinfection. Dendritic cells (DCs) including myeloid DCs …
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