Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Respiratory Syncytial Virus"”.
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections (LRTIs) in young children and of hospitalization for any reason in the first year of life. Beside supportive management, specific treatments for severe RSV LRTIs are not yet available and the development of …
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A guinea pig model of human respiratory syncytial virus lung infection
Children who have an episode of acute respiratory syncytial virus (RSV) bronchiolitis are at increased risk for developing asthma, a disorder characterized by reversible airway obstruction, airway hyperresponsiveness and airway inflammation. Because latent or persistent pulmonary viral infections …
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Preliminary Analysis of Vital Proteins of the Human Respiratory Syncytial Virus
Human Respiratory Syncytial Virus infects the vast majority of children under the age of two and reoccurs in adulthood. It is a serious global problem as severe infection and death can result in the very young or very old and in immunocompromised people. The related bovine Respiratory Syncytial …
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Developing a Plant-Based Vaccine Against the Respiratory Syncytial Virus (Rsv)
The progression towards fruit-ripening is a highly coordinated process. Fruit softening is the result of polygalacturonase (PG) enzyme activation. The fruit-ripening promoter and the terminator regions from PG were sequenced. BLASTn analysis reveals sequence homology to genes involved in ethylene …
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Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
As respiratory syncytial virus (RSV) is a respiratory pathogen that causes significant morbidity and mortality in infants, there has always been great interest in the development of a vaccine. In the 1960s, children were immunized with formalin-inactivated (FI)-RSV vaccines. Not only did these …
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Antikörper-Entwicklung nach Respiratory Syncytial Virus (RSV)-Infektion bei Frühgeborenen und Säuglingen
Das RS-Virus ist die Hauptursache für Erkrankungen des unteren Respirationstraktes bei Säuglingen und Kleinkindern. In einer prospektiv durchgeführten Studie im Winterhalbjahr 1994/95 wurden 29 nosokomial (Studie 1) und 35 extern (Studie 2) mit dem RS-Virus infizierte Kinder untersucht. Das …
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Role of Dendritic Cells in Pathology of Respiratory Syncytial Virus Infection in Neonates
<p>Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis in children. We have shown that neonatal mice respond to primary RSV infection with T helper type 2 (Th2) biased immune responses, which are enhanced following reinfection. Dendritic cells (DCs) including myeloid DCs …
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Respiratory Syncytial Virus-bedingte Hospitalisationen bei einer Kohorte von Frühgeborenen im Münchner Raum
… einer Prophylaxe von Infektionen durch das Respiratory Syncytial Virus, die mit dem seit 1999 in Deutschland zugelassenen monoklonalen Antikörper Palivizumab möglich ist, werden regionale Daten zu Häufigkeit und prädisponierenden Faktoren schwerer RSV-Infektionen benötigt. Die vorliegende …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
Detection of invading viruses by pathogen recognition receptors (PRRs) first illicits an innate immune response which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the …
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The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
Respiratory Syncytial Virus (RSV) is the leading cause of epidemic respiratory tract illness in children worldwide. Although the mechanisms of RSV-induced airway disease are unknown, experimental evidence suggests that early local inflammatory processes serve as major initiating events in the …
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Heligmosomoides polygyrus-induced serum factors limit respiratory syncytial virus titres: a potential role for CCL8
… inflammation caused by a Type 1 immune response. Respiratory syncytial virus (RSV) is one of the most common viral respiratory infections among infants, young children, immunocompromised and elderly individuals. Infections with RSV lead to high rates of infant hospitalisation and mortality amongst …
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A Study of the Membrane Binding Properties of the Matrix Protein from Human Respiratory Syncytial Virus
… structure of the matrix (M) protein from human respiratory syncytial virus (RSV), and its interactions with model membranes composed of a range of lipids, which have been characterized using a variety of techniques. The M protein was expressed in E. coli with a histidine tag and purified by …
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Long-term effect of respiratory syncytial virus (RSV) infection on children: a prospective longitudinal birth cohort study in Bangladesh
BACKGROUND: Respiratory Syncytial Virus (RSV) is a leading cause of illness among neonates and young infants. In 2019, an estimated 33 million [95% CI: 21·6-50·3) RSV-associated acute lower respiratory infected (RSV-ALRI) episodes occurred worldwide in children younger than five years, and 101,400 …
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Developing a diagnostic assay for Pneumocystis jirovecii pneumonia and investigating the interaction of Pneumocystis murina and respiratory syncytial virus during co-infection in mice
… severity. In the Drakenstein Child Health Study, respiratory syncytial virus (RSV) was the most prevalent cause of pneumonia in children under 5 years. Furthermore, seroprevalence studies reveal that the majority of children under 4 years would have been exposed to P. jirovecii, suggesting that …
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The Interplay of RSV and IFITs: A comprehensive analysis of human and bovine Interferon-Induced Proteins with Tetratricopeptide Repeats induction and interaction with human and bovine Respiratory Syncytial Virus
… IFIT proteins are species-, cell type-, tissue-, virus-, and inducer-specific. Most mammals, including Homo sapiens and Bos taurus, express four IFITs: IFIT1, IFIT2, IFIT3, and IFIT5. These proteins exert their antiviral action through mechanisms well described in human systems, involving the …
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Acute lower respiratory tract infection in infancy: a seven year follow-up study
Seven years after hospitalisation for acute lower respiratory tract infection in infancy, 200 children and their case -controls were assessed for respiratory status and epidemiological characteristics. The index group comprised 100 cases where respiratory syncytial virus had been responsible for …
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Mathematical model for tripledemic disease (COVID-19, RSV, and Influenza)
… circulation of COVID-19, Influenza (Flu), and Respiratory Syncytial Virus (RSV), collectively termed the ”Tripledemic,” poses substantial public health challenges due to their overlapping transmission patterns and compounded healthcare demands. The discovery of COVID-19 vaccines such as Moderna …
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Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape
Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1 and NS2. We show that both BRSV NS proteins …
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RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
… countries carry the largest burden of Respiratory syncytial virus (RSV) disease, with most deaths occurring in these settings. This study aimed to investigate the burden of RSV disease in South African children hospitalised with lower respiratory tract infection (LRTI), with specific …
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