Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Resistome"”.
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The Role of the Poultry Litter Resistome in the Transmission of Antimicrobial Resistance to Salmonella
… poultry litter significantly reduces the litter resistome. Several processes (ex. composting) are currently being examined to identify one that ameliorates poultry litter.
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The role of antibiotics metaphylaxis on developmental dynamics of fecal microbiota and persistence of antimicrobial resistome in piglets
… structure, and their accompanying antimicrobial resistome in neonatal piglets. Forty-eight litters were blocked to one of six treatments; Control (CONT), TUL, CCFA, CHC, OTC and PPG. Two piglets per litter were individually identified and weights and deep fecal swabs were collected at days 0 …
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Disabling the intrinsic resistome of Mycobacterium tuberculosis: elucidating hierarchies of DNA repair and mutagenesis that undermine current antibiotic efficacy
DNA damage repair mechanisms are critical to the adaptive evolution of Mycobacterium tuberculosis as obligate human pathogen, including the emergence of drug-resistance during anti-tuberculosis (TB) chemotherapy. In experimental models, DnaE2-dependent translesion synthesis (TLS) and UvrB-dependent …
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Resistome, virulome and mobilome of nasal staphylococci from healthy humans and animals: A One Health approach with public health implications
La resistencia a los antimicrobianos (RAM) y la patogenicidad de estafilococos constituyen uno de los principales desafíos de salud mundial que deben abordarse mediante un enfoque holístico de "Una sola salud". El estudio de este género bacteriano en la microbiota nasal de humanos y animales sanos …
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Pinnipeds as sentinels of antimicrobial resistance: mapping antimicrobial resistance genes in the waters of the United Kingdom
… and characterization of the grey seal gut resistome and use associated telemetry data to evaluate possible sources and sinks of AMR in the waters surrounding the UK.<br/>In Chapter Two, I used a meta-analysis and systematic review to examine the presence and prevalence of bacteria isolated …
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The Comparative Risk of Antimicrobial Resistance Transfer from Pig, Poultry and Bovine Manure to Grassland
… environment as well as altering the indigenous resistome and microbiome. Grassland consists of ~70% of global agricultural land and is a vital source of food for livestock. The phyllosphere of plants is an under-researched area regarding the impact of agricultural management practices. …
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Integrative Metagenomic Approaches to Study Antibiotic Resistance Genes and Microbial Functions in the Preterm Infant Gut Microbiome
… colonization during this period shapes the resistome, understanding the factors driving ARG distribution and persistence are essential. This thesis investigated the distribution and genomic context of ARGs in the gut microbiome of preterm infants during the first six month of life. The two …
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Effects of dietary components on antibiotic resistance using mechanistic and plasmid based studies
… locations worldwide. The microbiome and mobile resistome was assessed over time. A more stabilised microbiota was found to develop as the birds age, which may be better established to harbour the increased number of resistance plasmids identified in the older birds. The effect of MRF on the …
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ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
… (SNP call) and to investigate the Virulome and Resistome. Briefly, 288 non-synonymous SNPs (nsSNPs) were found in the resistant strain, among these 21 nsSNPs were considered having a disruptive (high) impact in the encoded proteins (e.g. AgrA, TpiA, Spa); the remaining nsSNPs had a moderate …
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Multiple sequence recovery: theory and applications
… attempting to characterize the antibiotic resistome of a metagenomic sample. We begin by proving the statistical consistency of two different estimators for the set of haplotype sequences: the maximum likelihood estimator and a clustering method that minimizes the worst-case bit error …
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Elucidation of mechanisms of antibiotic subversion in mycobacteria
… the role of various components of the "intrinsic resistome" that limit the efficacy of antitubercular agents. The DNA damage response: the SOS response was hypothesized to play a role in antibiotic- mediated cellular death, and that disabling the mycobacterial SOS response, by generating …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
… as well as the composition of the NP antibiotic resistome using shotgun metagenomic sequencing. Methods: NP swabs were collected every second week from birth through the first year of life from 137 infants who were immunized with 2+1 doses of PCV13. These were the first 137 infants enrolled in …
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Advancing Monitoring and Mitigation of Antibiotic Resistance in Wastewater Treatment Plants and Water Reuse Systems
… monitoring AR at a WWTP by characterizing the resistome (i.e., full profile of ARGs) and microbiome across eight sampling events via metagenomic sequencing, complemented by antibiotic data. The WWTP significantly reduced the total load of ARGs and antibiotics, although correlations between ARGs …
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Effect of Standard Post-harvest Interventions of Fresh Vegetables on Bacterial Community Dynamics, Pathogen Survival and Antibiotic Resistance
… relative abundance of ARGs, also known as the “resistome,” were profiled by shotgun metagenomic sequencing and qPCR. Addition of a sanitizer during wash, storage temperature, and duration of storage affected the bacterial community structures on carrots, represented by the weighted Unifrac …
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… characterisation. Conclusion A diverse resistome was observed in CRSM, which was also reflected phenotypically, with blaOXA-48-like the most common carbapenemase. Though distinct clusters were observed, no clonality was noted, and a limited number of isolates shared plasmids. This study …
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Change in the Structure of Soil Microbial Communities in Response to Waste Amendments
… and the community resistance to antibiotics (“resistome”) which in turn increases the potential threat of antibiotic resistance genes. While another part of this study will determine changes in integrons and specific ARGs, this project will focus on changes in bacterial communities and the …
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ZOONOSI, RESISTENZE ANTIMICROBICHE E INNOVAZIONE NELL¿ALLEVAMENTO DEL BOVINO DA LATTE: APPROCCI INTEGRATI SECONDO IL PARADIGMA ONE HEALTH
… bacterial strains in milk, assess the milk resistome, and propose innovative solutions for the control of contagious mastitis. To evaluate the risk associated with zoonotic pathogens and antimicrobial resistance genes, epidemiological and genomic analyses of bacterial strains were integrated …
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Understanding the intrinsic antibiotic resistance in Lysobacter enzymogenes, a ubiquitous environmental bacterium
… resistomic analyses identified the core resistome of Lysobacter and also revealed potential genes related to the antibiotic resistance profiles in LeC3 and LaATCC29479. Second, screening two Tn5 transposon mutant libraries of LeC3 recovered 12 and 19 mutants with decreased ampicillin and …
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Enterococci and its enterocins as an alternative to antibiotics in poultry affected by necrotic enteritis
… whole genome sequencing (WGS) and data on their resistome, virulome, plasmidome, toxin genes and multilocus sequence typing were analysed. The results showed that the tet genes (associated with tetracycline resistance) were the most common resistance genes detected and, interestingly, two …
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