Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Resistance phenotypes"”.
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Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates
… a better understanding of biofilm antibiotic resistance and possible roles for cell-cell communication may lead to new therapeutic options. While many fascinating findings come from studies using NTHi lab strains, the results from any one strain do not necessarily represent the entire …
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MODELING AND MINING ANTIMICROBIAL RESISTANCE IN HUMAN AND ANIMAL POPULATIONS
… and animal populations. Resistant bacteria and resistance genes spread between individuals through direct and indirect pathways, such that antimicrobial use in one population can result in increased morbidity and mortality from resistant bacteria in another population. In particular, there is a …
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ΚΑΤΑΝΟΜΗ ΒΙΟΤΥΠΩΝ ΚΑΙ ΟΡΟΤΥΠΩΝ ESCHERICHIA COLI ΣΕ ΚΛΙΝΙΚΑ ΥΛΙΚΑ. ΣΥΣΧΕΤΙΣΗ ΦΑΙΝΟΤΥΠΩΝ ΑΝΤΙΣΤΑΣΕΩΣ ΚΑΙ ΟΡΟΤΥΠΩΝ
… WERE FURTHER CLASSIFIED TO BIOTYPES AND RESISTANCE PHENOTYPES. FOR THE CLASSIFICATION TO BIOTYPES, 25 BIOCHEMICAL REACTIONS WERE USED. SEROTYPING WAS PROCESSED WITH 36 MONOVALENT ANTISERA WHILE SUSCEPTIBILITY TO ANTIBIOTICS WAS CARRIED OUT WITH THE USE OF STANDARDIZED 13 SINGLE DISC …
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Multivariate Methods for the Study of Beta-lactam Resistance in Streptococci
… efforts to conduct large-scale surveillance of resistance in circulating bacterial populations. While these datasets have provided a rich source of information to study drug resistance, they have also highlighted its complex, multivariate nature, involving correlations both within and between …
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Using wildlife to biomonitor for antimicrobial resistance in the Scottish environment
Antimicrobial resistance (AMR) is a threat to global health. Surveillance of AMR<br/>bacteria in wildlife host is key to understanding and tracking their spread<br/>throughout our environment. We established baseline data on the prevalence of<br/>AMR E. coli in Scottish wild deer, utilising faecal …
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A Genetic Approach towards Modulating Pre-Harvest Pod Shatter in Brassica napus (Oilseed Rape)
… mapping population, segregating for Pod Shatter Resistance (PSR), termed POSH 1-3 exhibited a range of shatter resistance phenotypes. A Random Impact Test (RIT) was used to measure the difference between levels of PSR in population lines. An assessment of pod physiology among these lines revealed …
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Synthetic biology tools for sensing and evolving microbes: CRISPR-diagnostics and transposon-mediated genome re-wiring
… diverse carbon source utilization and antibiotic resistance phenotypes. Through the implementation of barcode-based tracking and longitudinal next-generation sequencing, I then re-construct transposon lineages within the genomes of host cells and investigate the impact of environmental complexity …
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Investigation of Cell-wall Targeting Strategies to Combat Antibiotic Resistance in Staphylococcus Aureus
… because there is extremely fast development of resistance even to new antimicrobials. This research aims to explore novel therapeutic and mechanistic approaches focused on cell wall regulation that overcome resistance. Following a detailed investigation, a β-lactam enhancer was identified and …
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Mecanismos de resistencia a antibióticos macrólidos, lincosamidas y estreptograminas en streptococcus y enterococcus
… macrolide, lincosamide and streptogramin (MLS) resistance mechanisms in Streptococcus and Enterococcus in La Rioja, from 1996 to 2001. Distribution of erythromcyin resistance phenotypes and involved mechanisms were studied for both genera, as well as temporary evolution and clonal diversity for …
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Analyses of diverse stresses, including hypoxia, cyanide, and hypergravity in Caenorhabditis elegans
… modulators that function to ultimately enable resistance and survival. In this dissertation I used Caenorhabditis elegans as a model to study the effects of a variety of stresses including the response to cyanide, hypoxia, and hypergravity.</p> <p>Chapter 2 of this thesis focuses on …
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Epidemiology of antimicrobial resistance at the livestock-human interface in an urban environment: a One Health approach
… current evidence regarding transmission of drug resistance between food animals and humans is limited and that similarity of AMR bacteria or AMR determinants in the two populations does not, by itself, provide information on directionality of transfer. I highlight the need to use high resolution …
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The Genetic Architecture Of Quantitative Disease Resistance In Maize
… the genetic basis for quantitative disease resistance (QDR) in plants. The focus of these studies was the economically important disease of maize (Zea mays L. ssp. mays), northern leaf blight (NLB, caused by Setosphaeria turcica L. anamorph Exserohilum turcicum). The maize nested association …
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Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation of P53 By Non-Cross-Resistant Platinum Analogs
… <p><strong>CIRCUMVENTING CISPLATIN RESISTANCE IN OVARIAN CANCERS THROUGH REACTIVATION OF P53 BY NON-CROSS-RESISTANT PLATINUM ANALOGS</strong></p> <p><strong>Michelle Martinez-Rivera, B.S.</strong></p> <p><strong>Advisory Professor: Zahid H. Siddik, Ph.D.</strong></p> <p>Cisplatin …
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Regulation of plant innate immunity: the role of protein import and the novel MOS4-associated complex
… pathogens by the products of specialized host Resistance (R) genes. Consequently, the pathogen is stopped at the site of infection. A unique dominant mutant in Arabidopsis thaliana, snc1, constitutively expresses pathogensis-related (PR) genes and exhibits enhanced resistance to bacterial and …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
… is often limited by the development of multidrug resistance. The most common form of resistance to these agents arises from the overexpression of drug efflux transporters. Extensive research efforts have attempted to develop colchicine binding site inhibitors, which are reported to be …
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Antibiotic Resistance Profiles and Population Structure of Healthcare-associated and Community-associated Staphylococcus aureus isolated in Fort Portal, Western Uganda
… infectious pathogens at bay, but with cases of resistance ever increasing, those same pathogens have the potential to reverse decades of medical progress, creating one of the biggest threats to global health, food security and development in the world today. The impact of antimicrobial …
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Defining the Aetiology and Antimicrobial Susceptibility Patterns of the Predominant Bacteria Associated with Bloodstream Infections at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam
… According to many multinational antimicrobial resistance surveillance schemes, Asia represents a substantial reservoir of clinically relevant antimicrobial resistant genes. These genes include extended spectrum Beta lactamases (ESBLs) and AmpC lactamases in the Enterobacteriaceae, …
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Nasopharyngeal carriage with Staphylococcus aureus in healthy children during the first year of life - The Drakenstein Child Health study
… respectively. Constitutive erythromycin resistance was identified in 1.7% (n=12), whereas the inducible MLSB phenotype (ICR) was observed in 2% (n=18) of isolates. All isolates were susceptible to tigecycline, linezolid and mupirocin. A strong relationship between the spa-clonal complexes …
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Resistencia a beta-lactámicos y fluoroquinolonas en Salmonella enterica. Mecanismos moleculares y elementos de movilización génica
… first objective of this thesis was to study the resistance phenotype and its relation with the serotype in 280 S. enterica isolates obtained from Hosp. San Pedro in Logrono (2007-2009) and Hosp. Clinico Universitario Lozano Blesa in Zaragoza (2009-2010). The main serotypes were Typhimurium (52%) …
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… of multi-drug efflux pumps belonging to the Resistance-Nodulation- Division family of exporters has been shown to contribute to both intrinsic and acquired resistance among Pseudomonas aeruginosa. These pumps are able to recognize and export diverse compounds including several classes of …
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