Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Resiquimod"”.
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… delivery of the immunomodulator R848 (or Resiquimod), a poorly soluble adjuvant for a melanoma vaccine. Third, nanodroplets of one of the liquid polymers were embedded in mucoadhesive wafers and were evaluated for spatially defined drug delivery to engineered tissues. Lastly, exogenously …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
… co-delivery of monophosphoryl lipid A (MPLA) and Resiquimod (R848) achieved a considerably higher antibody titer and brain nicotine reduction than only using MPLA or R848 alone as adjuvants. Collectively, the findings from this study may lead to a better understanding of the impact of multiple …
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Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
… acid (TLR3 agonist) or resiquimod (TLR7/8 agonist) within the same hNP scaffold yielded the highest serum antibody levels, improved antibody affinity, and the greatest attenuation of brain drug exposure following oxycodone challenge, illustrating the translational value …
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TUMOR-TARGETED RELEASE OF IMMUNOSTIMULATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF IMIDAZOQUINOLINE-BASED PRODRUGS AND ANTIBODY CONJUGATES
Different strategies have been proposed in order to achieve the targeted delivery of anticancer agents at the tumor site. Amongst the different delivery vehicles proposed, antibody drug conjugates (ADCs) have been especially successful in the clinic. Recently, the involvement of the immune system …