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Showing 1 to 2 of 2 for “"Resin Glycoside"”.
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Conformationally-Controlled Late-Stage Modifications for SAR Studies of the C-3-Glcp Moiety of Ipomoeassin F
<p>The resin glycoside, ipomoeassin F has been shown to be extremely potent against multiple cancer lines (IC50 = 4.2-36 nM). However, the mechanism of action of this potent and complex natural product is still not fully understood. The α,β-unsaturated esters of the glucosyl moiety have been shown …
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Aglycon Modifications of Ipomoeassin F: Synthetic Route Development and Analog Synthesis to Enable Further SAR Studies
<p>The ipomoeassin family of resin glycosides were discovered to have a high potency against numerous cancer cell line, with ipomoeassin F being the most potent among the family of natural products. Interestingly, one of the few differences between ipomoeassin F and the other compounds is the …